Disease: neurological disorders

Mercury Content in Three Edible Wild-Growing Mushroom Species from Different Environmentally Loaded Areas in Slovakia: An Ecological and Human Health Risk Assessment

Researchers tested three types of edible mushrooms from 60 locations across Slovakia to measure their mercury content and potential health risks. Mushrooms grown in polluted soils, especially former mining areas, accumulated dangerous levels of mercury, particularly in the mushroom caps. The study found that while some mushroom species are safer than others, consuming mushrooms from contaminated areas could pose serious health risks to both adults and children.

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ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

ELAV/Hu proteins are molecular machines that control how cells read and use genetic instructions. Found mostly in the brain and nervous system, these proteins help manage which genes get turned on or off, which is crucial for proper brain development and function. When these proteins go wrong, they can contribute to serious diseases like Alzheimer’s, Parkinson’s, cancer, and autism, making them promising targets for new treatments.

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Influence of Culture Conditions on Bioactive Compounds in Cordyceps militaris: A Comprehensive Review

Cordyceps militaris is a medicinal fungus used traditionally for treating fatigue, boosting immunity, and managing various health conditions. This comprehensive review explains how different growing methods, nutrients, light, temperature, and substrate materials affect the production of beneficial compounds in the fungus. The findings show that mixing grains with insect materials and using specific light conditions can significantly increase production of cordycepin, the most promising compound for cancer and immune health. The review identifies that more standardized growing methods and better understanding of the fungus’s metabolism are needed to make large-scale production practical and affordable.

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Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant

Researchers studied three genetic mutations in GABA_B receptors that cause severe epilepsy and developmental problems in children. They found that these mutations prevent the receptors from reaching the cell surface and cause excessive calcium buildup in nerve terminals, leading to overexcitability. Using a special drug compound that enhances GABA_B receptor activity, the team was able to reverse these harmful effects, offering a potential new treatment strategy for affected patients.

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Assessment of the Impact of Metals in Wild Edible Mushrooms from Dambovita County, Romania, on Human Health

This study examined 18 types of wild mushrooms commonly eaten in Romania to measure their metal content. Researchers found that while mushrooms provide important minerals like iron and zinc, some species accumulate harmful metals like cadmium and chromium. Children are at greater risk from eating these mushrooms than adults because their smaller bodies absorb proportionally more of the contaminants. Some mushroom species pose significant cancer risks from metal exposure.

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Fungal β-Glucans: Biological Properties, Immunomodulatory Effects, Diagnostic and Therapeutic Applications

β-glucans are natural substances found in yeast and fungi that help boost the immune system and fight cancer. They can be measured in blood to diagnose serious fungal infections and may help prevent common illnesses like colds and respiratory infections. Recent research suggests they could be useful additions to vaccines and may help patients recovering from COVID-19.

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