Disease: mycoses

Past, present and future of antifungals: Advancements in mechanisms of action and resistance

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Fungal infections are a growing global health threat, especially for people with weakened immune systems, causing millions of deaths annually. Currently available antifungal drugs are limited and increasingly face resistance, making them less effective over time. This special collection of research papers explores new approaches to treating fungal infections, including novel drugs, combination therapies, and alternative treatments to overcome resistance. Scientists and doctors hope these advances will help save more lives by providing better options for treating serious fungal diseases.

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Functional Amyloids in Adhesion of Non-albicans Candida Species

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Candida fungi cause common infections and form tough biofilms that resist treatment. These fungi stick to body surfaces using proteins called adhesins that form amyloid-like structures. Researchers found that special peptides can block these amyloid structures in several Candida species, preventing them from sticking to cells and potentially offering a new way to fight these infections.

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Past, present and future of antifungals: Advancements in mechanisms of action and resistance

mycolabadmin

Fungal infections are a growing global health problem, particularly for people with weakened immune systems, causing millions of deaths annually. Current antifungal medications are limited and increasingly ineffective due to drug-resistant fungi. This special issue explores new treatment strategies including novel drugs, combination therapies, and innovative approaches like nanoparticles and antimicrobial peptides to combat these serious infections.

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Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion

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Scientists who study fungi have been working to update how fungal species are named to match modern genetic understanding. A recent proposal tried to create rules for how clinical laboratories should report fungal names, but experts are concerned that the new framework has inconsistencies and may actually cause more confusion rather than clarify things. The authors of this letter point out that some fungi get special naming considerations while others don’t, and worry that allowing multiple names for the same organism contradicts years of effort to use one standard name per species.

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The ethnomycological knowledge of Karajá indigenous people from Bananal Island, Brazil

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Researchers studied how the Karajá indigenous people of Brazil understand and use fungi in their daily lives. While the Karajá don’t eat mushrooms as food, they recognize various fungi in their environment and use them for medicine, decorations in festivals, and childhood play. The study found that the Karajá have a neutral to slightly positive view of fungi, neither strongly liking nor disliking them, and their knowledge is passed down through families from childhood.

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