Disease: mild cognitive impairment

The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study

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This study examined whether Lion’s mane mushroom supplements could improve thinking speed and reduce stress in healthy young adults. Researchers found that a single dose improved how quickly people completed a mental challenge, and four weeks of daily supplements showed a trend toward reducing subjective stress. However, the study was small and found mixed results, including some negative effects on memory tasks, so more research with larger groups is needed to confirm these findings.

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Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease

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Mushrooms contain special compounds that may help protect the brain from Alzheimer’s disease. Research shows that eating mushrooms regularly could reduce the risk of memory problems and cognitive decline in older adults. These compounds work by reducing brain inflammation, protecting nerve cells, and helping the brain clear out harmful proteins. While these findings are promising, more human studies are needed to confirm how effective mushrooms are as an Alzheimer’s treatment.

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Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review

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Lion’s Mane mushroom shows promising benefits for brain health, potentially improving memory and reducing symptoms of anxiety and depression. It may help prevent cancer by triggering cancer cell death and supports digestive health by promoting beneficial gut bacteria. While generally safe, some people experience mild side effects like stomach discomfort or headaches, making it an accessible supplement for overall wellness.

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Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models

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This research shows that overweight and obese individuals have higher levels of a toxic compound called quinolinic acid in their bodies, which is linked to memory problems and brain shrinkage. The good news is that butyrate, a substance naturally produced by gut bacteria when we eat fiber, can protect against these harmful effects. Butyrate works by activating genes that produce brain-derived neurotrophic factor (BDNF), a protein essential for brain health and memory formation. The study suggests that increasing butyrate through diet or supplements could help prevent cognitive decline associated with obesity.

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Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus

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This study examined how different growing conditions and tissue types affect erinacine production in lion’s mane mushrooms. Researchers found that mycelium (the fungal threads) produced far more erinacines than fruit bodies, and that the type of growth medium significantly influenced which erinacines were produced. Interestingly, changes in erinacine production weren’t always reflected in gene activity levels, suggesting other cellular mechanisms control these beneficial compounds.

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Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction

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This study found that regular exercise helps protect the brain of diabetic people from cognitive decline by boosting a protein called NDRG2 in astrocytes (brain support cells). The research shows that NDRG2 works by blocking harmful immune responses that damage synapses (connections between brain cells). In diabetic mice, exercise improved memory and learning ability while increasing NDRG2 levels, while blocking this protein reversed these benefits.

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Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus

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Researchers studied how different growing conditions affect erinacine production in lion’s mane mushroom mycelium. They found that the type of nutrients provided (substrate) significantly influences which erinacines are produced, even when the genes responsible for making these compounds show similar activity levels. Mycelium produced much more erinacines than fruit bodies, and specific nutrients could be used to encourage production of specific beneficial compounds.

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