Metabolic dysfunction-associated steatotic liver disease (MASLD)

Ganoapplanilactone C from Ganoderma applanatum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

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Researchers found that a compound called ganoapplanilactone C from the medicinal mushroom Ganoderma applanatum can protect the liver from fat accumulation and damage caused by high-fat diets. In zebrafish studies, this compound worked better than a common cholesterol drug at reducing liver fat and improving liver health. The compound appears to work by activating a protein called AMPK that helps regulate how the body processes fats and reduces inflammation.

Glyoxalase 1 Inducer, trans-Resveratrol and Hesperetin–Dietary Supplement with Multi-Modal Health Benefits

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A dietary supplement combining trans-resveratrol and hesperetin activates a cellular defense mechanism called Nrf2, which increases production of an enzyme (Glo1) that helps eliminate harmful byproducts of sugar metabolism. This supplement improved multiple aspects of health in studies, including better blood sugar control, reduced inflammation, and improved liver function. The combination works better than either ingredient alone, and the trans form of resveratrol is much more effective than the cis form.

Novel Approaches in Glucose and Lipid Metabolism Disorder Therapy: Targeting the Gut Microbiota–Bile Acid Axis

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Your gut bacteria play a key role in how your body manages blood sugar and fats, working through molecules called bile acids. Researchers have discovered that certain foods, supplements, and herbs can improve this gut bacteria-bile acid interaction to help prevent or treat diabetes and obesity. This review explains how these natural interventions work and suggests promising new ways to treat metabolic diseases by harnessing your gut health.

Comparative Efficacy of Antrodia cinnamomea on Liver Function Biomarkers in Mice and Rats: A Network Meta-Analysis

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This study compared different extracts from a medicinal mushroom called Antrodia cinnamomea to see which ones work best for protecting liver health. Researchers analyzed data from multiple animal studies and found that extracts rich in compounds called triterpenoids were the most effective at improving liver function and reducing inflammation. The findings suggest that this mushroom could potentially become a natural treatment option for liver disease in the future.

Disease: Metabolic dysfunction-associated steatotic liver disease (MASLD)

Ganoapplanilactone C from Ganoderma applanatum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

Glyoxalase 1 Inducer, trans-Resveratrol and Hesperetin–Dietary Supplement with Multi-Modal Health Benefits

Novel Approaches in Glucose and Lipid Metabolism Disorder Therapy: Targeting the Gut Microbiota–Bile Acid Axis

Comparative Efficacy of Antrodia cinnamomea on Liver Function Biomarkers in Mice and Rats: A Network Meta-Analysis