Disease: Memory disorders (implied)

An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

This research reveals how two brain proteins called Spinophilin and Syd-1 work against each other to control how synapses strengthen during memory formation. When flies learn something new, these proteins reorganize the structure of synaptic connections through managing thin filaments called actin, which allows more neurotransmitters to be released. The study shows that this mechanism is essential for remembering information after learning, but not for the initial learning itself.

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