Disease: major depressive disorder

Attitudes toward psychedelics and psychedelic-assisted therapy among potential mental health service users and the general population in Australia

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This Australian study surveyed over 500 people about their views on psychedelics like psilocybin and MDMA for treating mental health conditions. Most people supported medical legalization of these substances, though many had safety concerns. Those with mental illness, those with prior psychedelic experience, and those with better knowledge of psychedelics were most supportive of their therapeutic use.

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Isolation and Antioxidant Mechanism of Polyphenols from Sanghuangporous vaninii

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Researchers found that a medicinal mushroom called Sanghuangporous vaninii grown on mulberry sawdust in China contains exceptionally high levels of polyphenols—powerful antioxidant compounds. They isolated and purified a particularly potent polyphenol mixture called HNMS3, which contains 33 different compounds. Through advanced molecular analysis, they discovered that HNMS3 works by activating eight key proteins in the body to fight oxidative stress, making it potentially beneficial for brain health and preventing nerve degeneration.

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Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1

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Regular exercise, especially high-intensity training, can help improve depression symptoms in young people by changing how immune cells in the brain function. The study shows that exercise increases production of a specific enzyme (CerS1) in microglia, which are the brain’s immune cells. This enzyme helps balance certain fatty molecules that reduce brain inflammation, ultimately improving mood and reducing depression-like behaviors. The findings suggest exercise works similarly to antidepressant medications for adolescent depression.

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Acute effects of psilocybin on attention and executive functioning in healthy volunteers: a systematic review and multilevel meta-analysis

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This comprehensive review examined how psilocybin affects thinking and attention. Researchers analyzed 13 studies and found that psilocybin slows down reaction times during tasks requiring focus and decision-making, though accuracy remains relatively stable. The effects increase with higher doses. Understanding these cognitive changes is important for both therapeutic applications and ensuring safe use of psilocybin in research and clinical settings.

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Specific Foods Associated with Depressive Symptoms among Young Adults and Their Bioactive Effects

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This research examined how specific everyday foods like milk, eggs, bananas, oranges, sweet potatoes, mushrooms, and kimchi may help reduce depression symptoms in young adults. The study found that people eating more of these foods had significantly lower rates of depression. These foods contain natural compounds like vitamins, minerals, and antioxidants that support brain health and mood regulation. While more research is needed, the findings suggest that dietary choices could be an important part of managing depression.

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Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD

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Researchers developed a new magnetic stimulation technique using tiny iron nanoparticles to precisely target a specific brain region called the paraventricular nucleus. When stimulated at 10 Hz, this region releases oxytocin, a hormone that improves social behavior. In mice with autism-like symptoms, one week of this treatment significantly improved their sociability and reduced anxiety, offering a promising non-invasive therapy for autism.

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Cordyceps militaris and Armillaria mellea formula alleviates depressive behaviors via microglia regulation in an unpredictable chronic mild stress animal model

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Two medicinal mushrooms, Cordyceps militaris and Armillaria mellea, when combined as a formula, can help reduce depression-like symptoms in stressed animals. The formula works by balancing immune cells in the brain called microglia and restoring normal chemical messenger function. This treatment shows promise as a natural alternative to conventional antidepressants with fewer side effects.

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