Disease: lomentosporiosis

Exploring the Siderophore Portfolio for Mass Spectrometry-Based Diagnosis of Scedosporiosis and Lomentosporiosis

Two dangerous opportunistic fungi that cause serious infections in vulnerable patients produce distinct chemical compounds called siderophores to help them acquire iron from their hosts. Researchers used advanced mass spectrometry techniques to detect and measure these compounds, finding that one fungus produces significantly more of these iron-scavenging molecules, which may explain why it causes more severe infections. These siderophores could potentially be used as diagnostic markers in medical laboratories to quickly identify these infections in patient samples.

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Clinical Significance and Therapeutic Challenges of Scedosporium spp. and Lomentospora prolificans Isolates in a Single-Center Cohort of Lung Transplant Recipients

This study examined rare but serious fungal infections caused by Scedosporium and Lomentospora in lung transplant patients. Of 576 transplant recipients, 11 (2%) developed these infections, which are difficult to treat due to natural resistance to most antifungal medications. The infection type greatly influenced outcomes, with disseminated Lomentospora infections causing 100% mortality despite treatment. The research highlights the urgent need for new diagnostic methods and more effective antifungal drugs to combat these emerging pathogens.

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Clinical Significance and Therapeutic Challenges of Scedosporium spp. and Lomentospora prolificans Isolates in a Single-Center Cohort of Lung Transplant Recipients

This study examined dangerous fungal infections caused by Scedosporium and Lomentospora species in lung transplant patients at a Spanish hospital. Researchers found these infections were uncommon but very serious, with high death rates especially from the Lomentospora type. Current antifungal drugs often don’t work well against these fungi, highlighting the need for better treatment options.

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