Disease: liver fibrosis

Ganoapplanilactone C from Ganoderma applanatum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

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Researchers found that a compound called ganoapplanilactone C from the medicinal mushroom Ganoderma applanatum can protect the liver from fat accumulation and damage caused by high-fat diets. In zebrafish studies, this compound worked better than a common cholesterol drug at reducing liver fat and improving liver health. The compound appears to work by activating a protein called AMPK that helps regulate how the body processes fats and reduces inflammation.

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Sea buckthorn bioactive metabolites and their pharmacological potential in digestive diseases

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Sea buckthorn is an ancient medicinal plant containing hundreds of bioactive compounds that show promise in treating digestive diseases like stomach ulcers, colitis, and liver problems. This comprehensive review of 85 scientific studies found that sea buckthorn’s active ingredients work through multiple mechanisms including reducing inflammation, fighting harmful bacteria, protecting the intestinal lining, and balancing gut bacteria. The research suggests sea buckthorn could become a valuable natural supplement for digestive health, though more clinical trials are needed to confirm optimal doses and long-term effectiveness in humans.

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Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Researchers studied how different growing methods affect the medicinal compounds produced by Taiwanofungus gaoligongensis, a rare fungus. By growing the fungus on different substrates including wood from specific trees, they found that certain growing methods produced much higher levels of beneficial compounds like antcins that have anti-cancer and anti-inflammatory properties. They also identified which genes control the production of these compounds, which could help improve cultivation methods to make the fungus more medicinally valuable.

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Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Scientists studied a medicinal mushroom called Taiwanofungus gaoligongensis to understand how different growing methods affect the production of beneficial compounds. They found that growing the mushroom in special bags with certain wood substrates produced far more of the valuable compounds (up to 12-fold more) compared to growing it on rice medium. By examining which genes were active in different growing conditions, they discovered how the mushroom’s cells control the production of these medicinal compounds, which could help farmers grow more potent medicinal mushrooms.

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Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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This study examined how different growing methods affect the medicinal compounds found in Taiwanofungus gaoligongensis, a rare Chinese medicinal fungus. Researchers discovered that growing this fungus on wood substrates from specific trees significantly increased production of beneficial compounds like antcins and antrodin C, which have anti-cancer and anti-inflammatory properties. By analyzing gene expression patterns, they identified key genes and regulatory mechanisms that control the production of these medicinal compounds, suggesting ways to improve cultivation methods for better medicinal value.

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Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

mycolabadmin

Scientists studied a medicinal mushroom species to understand how different growing methods affect its beneficial compounds. They found that growing the mushroom on specific wood substrates (from cinnamon trees) produced much higher levels of therapeutic compounds compared to rice-based cultivation. Using advanced molecular techniques, they identified the genes responsible for producing these medicinal compounds and how they are controlled, providing insights to improve mushroom cultivation for better health benefits.

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