Disease: liver cirrhosis

Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease

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Fatty liver disease is becoming increasingly common and current medications have side effects like dangerously low blood sugar. This review shows that natural plant-based compounds and traditional Chinese herbs can activate a key protein (AMPK) in the body that helps burn fat and regulate sugar levels. Over 30 different plant compounds from foods and herbs like ginger, curcumin, and ganoderma mushrooms have been shown to improve fatty liver disease by activating this protein through multiple beneficial mechanisms.

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Recent advances and role of melatonin in post-harvest quality preservation of shiitake (Lentinula edodes)

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Shiitake mushrooms are nutritious but spoil quickly after harvest due to their high water content and lack of protective skin. This review explores how melatonin and various preservation methods like proper cooling, special packaging, and drying can extend shelf life and maintain quality. Different techniques work by controlling moisture, slowing respiration, preventing browning, and controlling microbial growth. Combining multiple methods, such as vacuum cooling with special packaging, provides the best results for preserving the mushrooms’ taste, nutrition, and appearance.

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Cryptococcus: Emerging host risk factors for infection

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This scientific review examines why some people without HIV are getting serious Cryptococcus infections and becoming very sick. Researchers found that people with liver problems, kidney disease, diabetes, cancer, and autoimmune diseases face much higher risk. The review also identifies new drugs and therapies that can surprisingly increase infection risk, highlighting the importance of understanding individual patient factors when treating these dangerous fungal infections.

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One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia

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This editorial discusses how bacteria, viruses, and fungi interact in the lungs during severe pneumonia from COVID-19 or influenza. When mechanically ventilated patients with COVID-19 had bacterial infections detected, their immune systems released more inflammatory chemicals. However, the same pattern was not observed in influenza patients. Understanding how all these microorganisms work together may help doctors better treat these serious lung infections.

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