lichen amyloidosis – mycolab.ai

Fruiting body-associated Pseudomonas contact triggers ROS-mediated perylenequinone biosynthesis in Shiraia mycelium culture

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Scientists discovered that bacteria living inside medicinal mushroom fruiting bodies can trigger the production of powerful healing compounds called perylenequinones through direct physical contact. These compounds are being used to fight cancer and harmful bacteria through a therapy called photodynamic therapy. The study shows that when bacteria touch the mushroom’s cells, it causes the mushroom to produce more of these therapeutic compounds by creating controlled stress that activates specific genes.

Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures

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Hypocrellins are powerful compounds from fungi that can treat cancers and infections through light-activated therapy. Since wild sources are limited, scientists are growing these fungi in laboratory cultures and using special techniques to boost production. This review summarizes the best methods for producing hypocrellins, from choosing the right fungal strains to optimizing growing conditions and using natural stimulants to increase yields.

Glucose-6-Phosphate Dehydrogenase Modulates Shiraia Hypocrellin A Biosynthesis Through ROS/NO Signaling in Response to Bamboo Polysaccharide Elicitation

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Researchers discovered that a naturally derived compound from bamboo boosts the production of hypocrellin A, a promising cancer-fighting and antimicrobial agent made by a special fungus. By studying a key enzyme called G6PDH, they found that it acts as a molecular switch controlling hypocrellin production when the fungus senses bamboo components. This discovery enables cost-effective large-scale production of this powerful medicine through simple fermentation, potentially making novel cancer treatments and antibiotics more accessible.

Glucose-6-Phosphate Dehydrogenase Modulates Shiraia Hypocrellin A Biosynthesis Through ROS/NO Signaling in Response to Bamboo Polysaccharide Elicitation

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Researchers discovered that a specific enzyme called glucose-6-phosphate dehydrogenase (G6PDH) controls the production of hypocrellin A, a powerful therapeutic compound found in Shiraia fungi. When bamboo polysaccharides are added to fungal cultures, they trigger G6PDH activity, which then increases the production of signaling molecules that boost hypocrellin A biosynthesis. This finding could lead to better ways to produce this promising cancer-fighting photosensitizer at industrial scales using simple, cost-effective methods.

Disease: lichen amyloidosis

Fruiting body-associated Pseudomonas contact triggers ROS-mediated perylenequinone biosynthesis in Shiraia mycelium culture

Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures

Glucose-6-Phosphate Dehydrogenase Modulates Shiraia Hypocrellin A Biosynthesis Through ROS/NO Signaling in Response to Bamboo Polysaccharide Elicitation

Glucose-6-Phosphate Dehydrogenase Modulates Shiraia Hypocrellin A Biosynthesis Through ROS/NO Signaling in Response to Bamboo Polysaccharide Elicitation