Disease: leishmaniasis

Domestication of a magic therapeutical wine glass fungus (Podoscypha petalodes) from Pakistan

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Researchers successfully grew Podoscypha petalodes, a medicinal mushroom known as wine glass fungus, under controlled conditions for the first time. The best growth was achieved using a mixture of sawdust and tea waste at 28°C, which produced high yields in just 10 days. This breakthrough means that this therapeutic fungus, which has antiviral and anti-cancer properties, can now be cultivated year-round commercially instead of relying on rare wild specimens.

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Optimized protein extraction protocol from human skin samples

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Researchers developed an improved method for extracting and analyzing proteins from human skin samples. Using specialized equipment and chemical treatments, they were able to identify about 6,000 different proteins in skin tissue, which is significantly more than previous methods could detect. This new protocol is particularly useful for studying skin diseases like fungal infections and could help identify new treatments by revealing how proteins change in diseased skin.

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Fruiting body-associated Pseudomonas contact triggers ROS-mediated perylenequinone biosynthesis in Shiraia mycelium culture

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Scientists discovered that bacteria living inside medicinal mushroom fruiting bodies can trigger the production of powerful healing compounds called perylenequinones through direct physical contact. These compounds are being used to fight cancer and harmful bacteria through a therapy called photodynamic therapy. The study shows that when bacteria touch the mushroom’s cells, it causes the mushroom to produce more of these therapeutic compounds by creating controlled stress that activates specific genes.

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Not everything that wiggles is a worm: Pseudoparasites in parasitology

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When examining patient samples under a microscope, parasitologists must be careful to distinguish real parasites from artifacts that only look like parasites. Items such as pollen, plant fibers, yeast, and food remnants can closely resemble parasitic organisms and lead to incorrect diagnoses and unnecessary treatment. By using proper training, multiple diagnostic techniques, and careful morphological evaluation, healthcare professionals can avoid these diagnostic errors and ensure accurate patient care.

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Chlorophyllum molybdites-synthesized manganese oxide nanoparticles (MnO-NPs): morphology, biocompatibility, and anticancer properties against liver cancer (HepG2) cell line

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Researchers successfully created tiny manganese oxide particles using a wild mushroom called Chlorophyllum molybdites through an environmentally friendly process. These nanoparticles showed strong cancer-fighting ability against liver cancer cells and were effective against a parasite that causes leishmaniasis. The particles were safe for human use with minimal damage to healthy blood cells, making them promising candidates for developing new cancer and parasitic disease treatments.

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