Invasive fungal infection – Page 3

Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report

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A 26-year-old patient with acute leukemia developed a rare fungal bloodstream infection caused by Magnusiomyces capitatus during cancer treatment. The infection was identified through advanced laboratory techniques including DNA sequencing and mass spectrometry. The patient was successfully treated with amphotericin B, highlighting the importance of rapid and accurate fungal identification for better patient outcomes.

Performance Evaluation of Five Real-Time PCR Assays for the Detection of Candida auris DNA

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Candida auris is a dangerous fungal infection that spreads in hospitals and resists common antifungal medications. Researchers compared five different rapid tests (PCR assays) to see which ones best detect this pathogen. The study found that different tests vary widely in their ability to detect the fungus, with some being much more sensitive than others. The findings highlight the need for standardized testing methods worldwide to ensure hospitals can reliably identify and control C. auris infections.

A zinc-chelating cyclic alkyl polyamine compound is efficient and safe in a murine model of multidrug-resistant Candida auris infection

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Researchers tested a new drug called APC6 that works by trapping zinc, which fungi need to survive. In mouse studies of a dangerous resistant fungus called Candida auris, APC6 saved all treated mice while most untreated mice died. The drug also reduced fungal infections in organs without causing serious side effects, suggesting it could become a new treatment option for serious fungal infections resistant to current medicines.

Invasive Rhinocerebral Mucormycosis Is a Rare Complication in Systemic Juvenile Idiopathic Arthritis Patient

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A 5-year-old girl with a serious joint disease called systemic juvenile idiopathic arthritis developed a dangerous fungal infection in her nasal cavity and brain area. The fungal infection, caused by a mold organism called Lichtheimia, occurred because her immune system was severely weakened by medications used to treat her arthritis. Doctors treated the infection with antifungal drugs and surgery, and the patient eventually recovered by switching to a different arthritis medication. This case highlights how the strong medications needed to control some childhood arthritis can unexpectedly cause serious fungal infections.

Invasive Saprochaete capitata Infection in an Immunocompromised Patient With Acute Myeloid Leukemia: A Case Report

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A 46-year-old man with blood cancer developed a serious fungal infection caused by Saprochaete capitata during chemotherapy. This rare but dangerous fungus was found in his blood and lungs, causing fever and breathing problems. The patient was successfully treated with a combination of two antifungal medications and fully recovered, though this infection typically has a high death rate.

Geotrichosis Due to Magnusiomyces capitatus: A Severe Emerging Invasive Fungal Disease

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A 71-year-old cancer patient receiving chemotherapy developed a severe blood infection caused by a rare fungus called Magnusiomyces capitatus. This emerging fungal infection caused septic shock and multiple organ failure despite treatment with antifungal medications. The case highlights how these rare fungi can be deadly in patients with weakened immune systems and emphasizes the importance of quick, accurate identification using advanced laboratory techniques to guide treatment decisions.

Epidemiology of mucormycosis in COVID-19 patients in northwest Iran: Rhizopus arrhizus as the predominant species

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This study found that COVID-19 patients in northwestern Iran who received high-dose steroid treatment developed serious fungal infections called mucormycosis. The infection was caused primarily by a fungus called Rhizopus arrhizus and affected mainly the sinuses and brain. The steroids used to treat COVID-19 weakened patients’ immune systems and triggered diabetes, both of which made them vulnerable to this dangerous fungal infection.

The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients

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This case report describes two rare instances where fungal infections were transmitted from organ donors to heart transplant recipients. One involved a Candida infection and the other involved Aspergillus fungus, both causing serious bloodstream and heart infections. The patients required extensive antifungal medications and multiple surgeries to survive their infections, though they experienced significant complications. These cases highlight the importance of careful screening of organ donors for undetected infections.

Cutaneous Purpureocillium lilacinum and Fusarium coinfection in a heart transplant recipient

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A heart transplant patient developed multiple nodular skin lesions caused by two rare types of mold fungi growing together. Doctors diagnosed the infection through skin biopsy and identified the fungi using laboratory techniques. The patient was successfully treated with the antifungal medication voriconazole for six months and made a full recovery without relapse.

Disease: Invasive fungal infection