Interstitial lung disease

Mitigating nickel-induced toxicity: the protective role of native probiotic strains on oxidative stress and inflammatory pathways in mice lung tissues

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This study examined how probiotic bacteria can protect lung tissue from damage caused by nickel exposure. Researchers gave mice nickel to cause oxidative stress and inflammation, then treated them with beneficial bacteria from four probiotic strains. The probiotics successfully reduced oxidative stress markers and inflammatory responses in the lung tissue by activating protective genes and deactivating inflammatory genes. This research suggests that probiotics could be a natural way to prevent lung damage from heavy metal exposure.

Distribution of fungal agents in the respiratory system of patients with underlying lung diseases; molecular identification and antifungal susceptibility profiles

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This research examined fungal infections in hospitalized patients with lung diseases in Iran, identifying which fungi were most common and which antifungal medications worked best against them. Researchers found that Candida albicans and Aspergillus flavus were the most prevalent fungi, particularly in COPD patients. Notably, some Candida isolates showed resistance to certain antifungal drugs, particularly voriconazole. The study emphasizes the importance of proper fungal identification and susceptibility testing for effective treatment.

Pulmonary Aspergilloma in a Non-adherent Systemic Lupus Erythematosus Patient Receiving Long-Term Immunosuppression: A Report of a Rare Case

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A patient with systemic lupus erythematosus (SLE), a chronic autoimmune disease treated with long-term immune-suppressing medications, developed a serious fungal lung infection called pulmonary aspergilloma. Despite the complexity of managing multiple conditions and extensive bilateral lung involvement, the patient was successfully treated with prolonged voriconazole antifungal therapy rather than surgery, emphasizing the importance of early recognition and tailored treatment in immunocompromised patients.

Phaeohyphomycosis due to Nigrograna chromolaenae in a cardiac transplant patient

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A 71-year-old heart transplant patient developed a slowly growing bump on his finger caused by a rare fungus called Nigrograna chromolaenae. Doctors initially tried common antifungal medications that didn’t work well, but the patient improved significantly when switched to posaconazole treatment. This is the first documented case of this particular fungus infecting a human, highlighting the importance of accurately identifying fungi to choose the right treatment.

Disease: Interstitial lung disease

Mitigating nickel-induced toxicity: the protective role of native probiotic strains on oxidative stress and inflammatory pathways in mice lung tissues

Distribution of fungal agents in the respiratory system of patients with underlying lung diseases; molecular identification and antifungal susceptibility profiles

Pulmonary Aspergilloma in a Non-adherent Systemic Lupus Erythematosus Patient Receiving Long-Term Immunosuppression: A Report of a Rare Case

Phaeohyphomycosis due to Nigrograna chromolaenae in a cardiac transplant patient