insulin resistance – mycolab.ai

Targeting Polycystic Ovary Syndrome (PCOS) Pathophysiology with Flavonoids: From Adipokine–Cytokine Crosstalk to Insulin Resistance and Reproductive Dysfunctions

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Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting millions of women that causes irregular periods, infertility, and metabolic problems. Flavonoids are beneficial plant compounds found in fruits, vegetables, and tea that show promise in treating PCOS by improving insulin sensitivity, reducing inflammation, and balancing hormones. While current medications have limited benefits and side effects, flavonoid supplements could offer a safer, natural way to address multiple PCOS problems simultaneously. However, more large-scale clinical studies are needed to confirm their effectiveness and establish optimal dosing.

Ganoapplanilactone C from Ganoderma applanatum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

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Researchers found that a compound called ganoapplanilactone C from the medicinal mushroom Ganoderma applanatum can protect the liver from fat accumulation and damage caused by high-fat diets. In zebrafish studies, this compound worked better than a common cholesterol drug at reducing liver fat and improving liver health. The compound appears to work by activating a protein called AMPK that helps regulate how the body processes fats and reduces inflammation.

Glyoxalase 1 Inducer, trans-Resveratrol and Hesperetin–Dietary Supplement with Multi-Modal Health Benefits

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A dietary supplement combining trans-resveratrol and hesperetin activates a cellular defense mechanism called Nrf2, which increases production of an enzyme (Glo1) that helps eliminate harmful byproducts of sugar metabolism. This supplement improved multiple aspects of health in studies, including better blood sugar control, reduced inflammation, and improved liver function. The combination works better than either ingredient alone, and the trans form of resveratrol is much more effective than the cis form.

Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences

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This research shows that taking a specialized supplement containing natural plant compounds along with eating a Mediterranean diet can significantly help people with fatty liver disease. The supplement works by reducing harmful stress molecules in liver cells and calming down inflammation. After three months of treatment, patients showed improved liver health markers, better cholesterol levels, and improved blood sugar control. The study demonstrates that combining diet and targeted supplements is more effective than diet changes alone.

Recent advances in natural polysaccharides for type 2 diabetes management: sources, structural characteristics, and mechanistic insights

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Natural polysaccharides from plants, mushrooms, and seaweed show promise as treatments for type 2 diabetes. These complex sugar molecules work through multiple mechanisms including improving how the body uses insulin, reducing inflammation and oxidative stress, and promoting beneficial gut bacteria. The effectiveness of these polysaccharides depends on their specific chemical structure, particularly their molecular weight and how their sugar units are linked together.

Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study

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Researchers tested a combination of special foods and supplements made from Mediterranean plants like tomatoes, pomegranates, and hazelnuts to see if they could help people with metabolic health problems. Over 4 weeks, older adults who consumed these foods daily showed improvements in muscle, bone quality, and liver health. The products tasted good and people stuck with them easily, suggesting this approach could be a practical way to improve health through diet.

Gut-Brain Axis in Obesity: How Dietary Patterns Influence Psychological Well-Being and Metabolic Health

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This review explains how our diet affects both our gut bacteria and our mental health through the gut-brain axis, a communication system between our digestive system and brain. Mediterranean diets rich in fiber and healthy foods support beneficial bacteria and mental well-being, while Western diets high in processed foods harm gut health and increase obesity risk. Emotional eating driven by stress and depression worsens obesity, but targeted dietary interventions with prebiotics, probiotics, and fiber can help restore balance and improve both physical and mental health.

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

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This research review explores how mushroom compounds called polysaccharides may help manage diabetes by reducing harmful stress on cells caused by high glucose levels. Scientists found that 104 different mushroom polysaccharides have anti-diabetic properties and can protect insulin-producing cells in the pancreas. These natural compounds show promise as a complementary treatment to conventional diabetes medications, potentially with fewer side effects than synthetic drugs.

Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease

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Fatty liver disease is becoming increasingly common and current medications have side effects like dangerously low blood sugar. This review shows that natural plant-based compounds and traditional Chinese herbs can activate a key protein (AMPK) in the body that helps burn fat and regulate sugar levels. Over 30 different plant compounds from foods and herbs like ginger, curcumin, and ganoderma mushrooms have been shown to improve fatty liver disease by activating this protein through multiple beneficial mechanisms.

Advancing Nutritional Science: Contemporary Perspectives on Diet’s Role in Metabolic Health and Disease Prevention

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This research collection shows how what we eat significantly impacts our metabolic health and ability to prevent diseases. Key findings include that eating more vegetables helps prevent metabolic syndrome in older adults, and certain dietary patterns combined with regular exercise reduce disease risk in young adults. The research also highlights the benefits of natural compounds like inulin and royal jelly for managing metabolic disorders, while emphasizing the importance of personalized nutrition approaches for rare conditions.

Disease: insulin resistance