insomnia – mycolab.ai

Long-COVID symptoms improved after MDMA and psilocybin therapy: A case report

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A 41-year-old woman with Long-COVID experienced severe symptoms including fatigue, depression, anxiety, headaches, and brain fog that didn’t improve with traditional treatments. She decided to try psilocybin mushrooms and MDMA with guidance from a therapist. After multiple dosing sessions over several months, she reported roughly 80-90% improvement in her symptoms and was able to return to work and resume her studies. While this single case is promising, more research is needed to determine whether these psychedelics are truly safe and effective for Long-COVID.

Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism

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Scientists studied how the medicinal mushroom Ganoderma lucidum changes as it grows, discovering that different growth stages contain different beneficial compounds. The budding stage was found to have the highest levels of powerful healing compounds called triterpenoids and steroids. This research helps identify the best time to harvest the mushroom to get maximum health benefits, improving both quality and standardized production for medicinal use.

Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine

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This review examines how psychedelic drugs like ketamine, MDMA, and psilocybin could offer new hope for people with PTSD by working on the brain differently than current medications. These compounds work quickly and help the brain form new neural connections that can help people process traumatic memories more effectively. When combined with therapy, these drugs show promise in reducing PTSD symptoms faster and more effectively than traditional antidepressants. The review also explains how doctors could use personalized medicine approaches using brain scans and genetic testing to determine which treatment would work best for each individual patient.

PolDrugs 2025: results of the third edition of the nationwide study on psychoactive substance use in the context of psychiatry and harm reduction

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This Polish study surveyed nearly 2,500 recreational drug users about their substance use patterns and mental health. The survey found that marijuana is the most commonly used illicit drug, but worryingly, most users don’t test what they’re taking or measure doses carefully. The study also revealed increasing use of mephedrone and other stimulants that are sending more people to hospitals, while interest in psychedelics is declining. Importantly, more people are now seeing psychiatrists and being honest about their drug use.

Psychedelic Mushrooms in the USA: Knowledge, Patterns of Use, and Association With Health Outcomes

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This study surveyed over 250 million representative American adults about their use of psychedelic mushrooms. Researchers found that about 1.7% of US adults used psychedelic mushrooms in the past year, primarily for general mental health and well-being. Interestingly, those who used them reported higher levels of depression and anxiety, suggesting people with mental health challenges may be self-treating with mushrooms. The findings highlight the need for evidence-based guidelines as more Americans explore psychedelics for health purposes.

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective

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Traditional medicines from plants, animals, and fungi contain chemical compounds that can interact with specific proteins in our cells called G protein-coupled receptors (GPCRs). These receptors control many important body functions and are targeted by about one-third of all FDA-approved medications. This review explains how scientists are discovering new therapeutic compounds from traditional medicines by systematically screening them against the complete library of human GPCRs, using advanced techniques to identify which compounds bind to which receptors. Famous examples include morphine from poppies for pain relief and compounds from ginseng that help regulate blood sugar.

The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts

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Different recipes made from Ganoderma lucidum mushroom have different health benefits. This study tested two recipes in mice and found that one (PGB) was better for reducing fatigue and improving exercise performance, while the other (GBS) was better for improving sleep quality. The research shows that how you prepare and combine medicinal mushroom ingredients matters for what health benefits you get.

Valorization of various lignocellulosic wastes to Ganoderma lucidum (Curtis) P. Karst (Reishi Mushroom) cultivation and their FT-IR assessments

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This research demonstrates how agricultural and forestry waste materials can be effectively converted into nutritious Reishi mushrooms through sustainable cultivation practices. Oak wood substrates produced the highest mushroom yields, while various agricultural wastes showed promising results for producing medicinal mushrooms. Using specialized spectroscopy techniques, scientists confirmed that the Reishi mushroom effectively breaks down and utilizes the complex plant materials in these waste substrates. This approach offers an environmentally friendly solution to waste management while producing valuable medicinal mushrooms.

Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

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Ganoderma, a medicinal fungus used in traditional medicine for over 2000 years, contains many beneficial compounds including triterpenes and polysaccharides. Scientific research has confirmed its effectiveness in treating various conditions including cancer, diabetes, infections, and inflammation. The fungus works by boosting the immune system, reducing oxidative stress, and directly inhibiting disease-causing organisms. Modern cultivation methods have made Ganoderma products widely available as supplements and medicines worldwide.

Melatonin-Producing Microorganisms: A Rising Research Interest in Their Melatonin Biosynthesis and Effects on Crops

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Scientists are discovering that certain microorganisms like yeast, algae, and bacteria naturally produce melatonin, the same molecule that helps humans sleep. These melatonin-producing microbes could help farmers grow healthier crops by sharing their melatonin with plants and protecting them from stress like drought and disease. This discovery offers an eco-friendly alternative to synthetic melatonin and could make agriculture more sustainable as climate change poses increasing challenges.

Disease: insomnia