inflammation – Page 6

Heat Treatment of Reishi Medicinal Mushroom (Ganoderma lingzhi) Basidiocarp Enhanced Its β-glucan Solubility, Antioxidant Capacity and Lactogenic Properties

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This study shows that heating dried Reishi mushrooms at 150°C for 20 minutes improves their health benefits. The heat treatment increases antioxidant compounds, makes the beneficial β-glucans more available, and enhances prebiotic effects that feed good gut bacteria while suppressing harmful bacteria. These findings suggest that properly heated Reishi mushroom products could be more effective as functional food ingredients without losing their medicinal properties.

Haplotype-Phased Chromosome-Level Genome Assembly of Floccularia luteovirens Provides Insights into Its Taxonomy, Adaptive Evolution, and Biosynthetic Potential

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Scientists have created the most detailed genetic map of the yellow mushroom (Floccularia luteovirens), a highly valued medicinal and edible fungus from the Tibetan Plateau. Using advanced sequencing technology, they mapped its 13 chromosomes and identified 15 pathways that the mushroom uses to make potentially useful healing compounds. The research also solved a long-standing mystery about the mushroom’s family tree, proving it is not actually related to Armillaria mushrooms as previously thought. This genetic blueprint opens new possibilities for developing medicines from this special fungus.

Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

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Ganoderma, a medicinal fungus used in traditional medicine for over 2000 years, contains many beneficial compounds including triterpenes and polysaccharides. Scientific research has confirmed its effectiveness in treating various conditions including cancer, diabetes, infections, and inflammation. The fungus works by boosting the immune system, reducing oxidative stress, and directly inhibiting disease-causing organisms. Modern cultivation methods have made Ganoderma products widely available as supplements and medicines worldwide.

Anticancer Activity of Demethylincisterol A3 and Related Incisterol-Type Fungal Products

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This review examines a group of rare fungal compounds called incisterols, with a focus on demethylincisterol A3 (DM-A3), which has shown promise as an anticancer agent. DM-A3 works through multiple mechanisms including blocking cancer cell signaling pathways, inhibiting specific enzymes, and reducing inflammation. The compound has demonstrated effectiveness against various cancer types in laboratory studies and showed tumor-reducing effects in animal models, suggesting potential for future cancer therapy development.

Insights into the special physiology of Mortierella alpina cultured by agar supported solid state fermentation in enhancing arachidonic acid enriched lipid production

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Researchers developed a new eco-friendly method to produce arachidonic acid (ARA), an important nutrient used in supplements, pharmaceuticals, and baby formula. Using a solid fermentation technique with the fungus Mortierella alpina, they achieved 1.6 times higher yields compared to traditional methods while reducing wastewater. By understanding how the fungus grows in different conditions and optimizing nutrients, they created a more sustainable and efficient production process.

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

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Researchers studied how special fungal compounds called elicitors can boost the production of healing substances in a medicinal mushroom called Sanghuangporus sanghuang. By analyzing genes and metabolites, they found that adding elicitors increased beneficial compounds like betulinic acid and 2-hydroxyoleanolic acid by up to 114-fold. These findings suggest a practical way to produce more medicinal compounds from this mushroom for health applications.

Chemical Composition and In Vitro Biological Activity of the Polar and Non-Polar Fractions Obtained from the Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim

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Siberian ginseng (Eleutherococcus senticosus) roots contain powerful antioxidant compounds that may help with inflammation, blood sugar control, and brain health. Researchers found that certain plant fractions were particularly rich in protective compounds like chlorogenic acid and caffeic acid. However, the study also discovered a concerning finding: these plant compounds protected cancer cells from chemotherapy drugs, suggesting people undergoing cancer treatment should be cautious about using this supplement.

Research advances in fungal polysaccharides: production, extraction, characterization, properties, and their multifaceted applications

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This comprehensive review examines fungal polysaccharides, which are complex sugar molecules found in mushrooms and fungi that have powerful health benefits. Researchers describe how to grow and extract these compounds from various fungi, and explain their uses in treating diseases like cancer, reducing inflammation, and boosting immunity. The review covers different growing and extraction methods used worldwide and discusses future directions for using these natural compounds in medicine and industry.

Innovative applications and therapeutic potential of oilseeds and their by-products: An eco-friendly and sustainable approach

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This review explains how leftover materials from oilseed processing, which are usually discarded as waste, contain valuable nutrients and healing compounds. These by-products can be used to make healthier foods like bread, burgers, and drinks, or turned into supplements and medicines. By using these materials instead of wasting them, we can reduce environmental problems, provide better nutrition, and create sustainable food products that help prevent diseases like diabetes and heart problems.

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

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Scientists studied how a special fungal treatment can boost the production of beneficial compounds in sanghuang mushrooms. Using advanced molecular analysis techniques, they found that the fungal elicitor significantly increased levels of healing compounds called triterpenes. The treated mushrooms produced 114 times more of one specific compound compared to untreated mushrooms. This research shows how we can grow medicinal mushrooms with higher levels of beneficial substances, which could help develop better treatments for various diseases.

Disease: inflammation