Disease: inflammation

Biologically active secondary metabolites from white-rot fungi

White-rot fungi are special mushrooms that can break down wood and produce unique chemical compounds with amazing health benefits. These compounds have been found to fight cancer, kill harmful bacteria, reduce inflammation, and protect nerve cells. Scientists are excited about using these natural fungal compounds to create new medicines and treat various diseases in the future.

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Soy Sauce Fermentation with Cordyceps militaris: Process Optimization and Functional Profiling

Researchers created a new type of soy sauce using Cordyceps militaris fungus, which contains health-promoting compounds. Using scientific optimization techniques, they found the best conditions for fermentation, resulting in a soy sauce with much higher levels of cordycepin and other beneficial compounds compared to traditional soy sauce. This product offers both the familiar taste of soy sauce and added health benefits, potentially serving as a functional food that people can use daily.

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Optimization of substrate formulation for Hericium erinaceus by replacing wood by straw and their effect on enzyme activities

Researchers developed an improved growing formula for lion’s mane mushrooms using agricultural waste materials like rice straw and corn cob instead of wood chips. This new formula grew mushrooms faster, with better harvest yields (89% biological efficiency), and produced mushrooms with higher nutritional value including more protein and beneficial minerals. The innovation helps solve resource conflicts with the forestry industry while reducing cultivation costs and environmental waste.

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Functional Approaches to Discover New Compounds via Enzymatic Modification: Predicted Data Mining Approach and Biotransformation-Guided Purification

Scientists are developing faster ways to discover new medicines from plants using two innovative methods. The first approach uses computer programs to predict which plant compounds can be chemically modified by enzymes to create new medicines with better properties. The second approach combines enzyme chemistry with traditional purification to directly isolate these modified compounds from plant extracts. These methods have successfully created new compounds with improved effectiveness against diseases like diabetes and cancer, often with much better solubility for medical use.

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From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids from Ganoderma species

This review examines special compounds called meroterpenoids found in Ganoderma mushrooms (commonly known as Reishi). Scientists have identified over 350 of these compounds from 14 different Ganoderma species. These compounds show promise for treating various health conditions including cancer, kidney disease, diabetes, and inflammatory disorders. The researchers also propose how these compounds are made inside the mushroom, which could help scientists produce them more efficiently for medical use.

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Valorisation of fish scales and bones: a sustainable source of bioactive proteins and collagen for nutraceuticals

Fish scales and bones, usually thrown away as waste, contain valuable collagen and proteins that can improve skin, joints, and overall health. New extraction methods can recover these beneficial compounds efficiently while being environmentally friendly. Studies show that taking fish collagen supplements daily can improve skin appearance, reduce joint pain, and lower blood pressure, making them a sustainable and natural health solution.

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Tour of Truffles: Aromas, Aphrodisiacs, Adaptogens, and More

Truffles are expensive underground mushrooms prized for their distinctive aromas and flavors, with prices reaching thousands of euros per kilogram. Their unique smell comes from over 300 different chemical compounds, many produced with help from bacteria living in the truffle. Beyond their use as luxury food, truffles contain compounds that may have health benefits including anti-inflammatory and antioxidant properties.

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Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

Researchers studied how adding olive mill waste to mushroom growing substrate affects the beneficial compounds in two edible mushrooms. They used advanced computer analysis of chemical data to find that this waste product increases healthy compounds like hericenones while reducing potentially harmful mycotoxins. This discovery could help make mushroom farming more sustainable and produce safer, healthier mushrooms for consumers.

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Implications of Pleurotus ostreatus solid-state bioprocessing on the nutritional composition, protein structure, and anti-hypertensive and anti-inflammatory potential of local beans (Phaseolus vulgaris L.)

Researchers used a type of oyster mushroom to ferment two local Spanish bean varieties, which dramatically improved their nutritional value. The fermented beans contained 23% more protein, higher levels of important amino acids, and had anti-inflammatory and blood pressure-lowering properties. These enhanced beans could be used to create healthier, more nutritious snacks specifically designed for children to help combat childhood obesity.

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Towards engineering agaricomycete fungi for terpenoid production

Mushroom-forming fungi, particularly species like shiitake and oyster mushrooms, naturally produce valuable compounds called terpenoids used in medicines, food, and cosmetics. Scientists are learning to genetically engineer these fungi to produce even larger amounts of these beneficial compounds, potentially making them as important to biotechnology as baker’s yeast and mold have been historically. This could create new sustainable sources for medicinal compounds and industrial chemicals.

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