Disease: immunosuppression requirements

Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Researchers studied how different sugars (fructose and sucrose) affect a fungus’s ability to produce cyclosporine A, an important drug used after organ transplants to prevent rejection. Using advanced protein analysis techniques, they found that fructose makes the fungus better at producing the drug, while sucrose makes it grow more mycelium (fungal threads). By identifying the specific proteins involved in each process, scientists can now develop better methods to produce more of this valuable medicine.

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Tracing the Origin and Evolution of the Fungal Mycophenolic Acid Biosynthesis Pathway

Mycophenolic acid is an important drug that helps transplant patients by preventing their immune systems from rejecting new organs. Scientists studied the genes that fungi use to make this drug and found it in several fungal species. They discovered that this ability to produce the drug evolved a long time ago in fungi but was lost in most species over time, remaining only in a few special fungi.

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