Disease: immunosuppression applications

Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Scientists studied how different sugar sources (fructose versus sucrose) affect the production of cyclosporine A, an important drug used to prevent organ rejection after transplants. Using advanced protein analysis techniques, they identified which proteins were more active in each sugar environment and discovered that fructose promotes drug production while sucrose promotes fungal growth. This research could help pharmaceutical companies produce cyclosporine more efficiently by identifying key proteins to enhance.

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