Disease: immune dysfunction

Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress

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Researchers successfully sequenced the complete genome of Cordyceps militaris CH1, a medicinal fungus used in traditional Chinese medicine. By exposing the fungus to light and analyzing gene expression and metabolite changes, they discovered that light stress activates key genes involved in producing cordycepin, the main active medicinal compound. This breakthrough provides a foundation for improving cordycepin production in artificial cultivation, making this valuable medicine more affordable and accessible.

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Research advances in fungal polysaccharides: production, extraction, characterization, properties, and their multifaceted applications

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This comprehensive review examines fungal polysaccharides, which are complex sugar molecules found in mushrooms and fungi that have powerful health benefits. Researchers describe how to grow and extract these compounds from various fungi, and explain their uses in treating diseases like cancer, reducing inflammation, and boosting immunity. The review covers different growing and extraction methods used worldwide and discusses future directions for using these natural compounds in medicine and industry.

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Influence of Culture Conditions on Bioactive Compounds in Cordyceps militaris: A Comprehensive Review

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Cordyceps militaris is a medicinal fungus used traditionally for treating fatigue, boosting immunity, and managing various health conditions. This comprehensive review explains how different growing methods, nutrients, light, temperature, and substrate materials affect the production of beneficial compounds in the fungus. The findings show that mixing grains with insect materials and using specific light conditions can significantly increase production of cordycepin, the most promising compound for cancer and immune health. The review identifies that more standardized growing methods and better understanding of the fungus’s metabolism are needed to make large-scale production practical and affordable.

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Exploring the Critical Environmental Optima and Biotechnological Prospects of Fungal Fruiting Bodies

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This research identifies the ideal growing conditions for fungal fruiting bodies like mushrooms, showing that temperature around 25°C, high humidity, and proper light exposure are key factors. The study reveals that exceeding these optimal conditions typically harms development more than staying slightly below them. Scientists discovered that fungal fruiting bodies have important uses in medicine, food production, and environmental cleanup, and new genetic technologies like CRISPR could improve cultivation methods for better yields and quality.

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Comparative transcriptome analysis reveals the genetic basis underlying the biosynthesis of polysaccharides in Hericium erinaceus

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Researchers studied six different strains of lion’s mane mushrooms to understand how they produce beneficial compounds called polysaccharides. Using advanced genetic analysis, they identified thirteen key genes responsible for making these health-promoting molecules. The study found that a strain called PZH-05 produced the most polysaccharides, and its genes were more active than in other strains. This research helps explain why lion’s mane mushrooms are effective for boosting immunity, fighting cancer, and managing blood sugar.

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A Chromosome-Scale Genome of Trametes versicolor and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis

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Scientists created a detailed map of the Trametes versicolor mushroom’s genetic code using advanced sequencing technologies. This medicinal mushroom is known for cancer-fighting and immune-boosting properties. The research discovered that light exposure increases the production of beneficial compounds called triterpenes, which may explain how this mushroom’s medicinal qualities work and could help scientists grow it more effectively.

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Assessment of the Impact of Metals in Wild Edible Mushrooms from Dambovita County, Romania, on Human Health

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This study examined 18 types of wild mushrooms commonly eaten in Romania to measure their metal content. Researchers found that while mushrooms provide important minerals like iron and zinc, some species accumulate harmful metals like cadmium and chromium. Children are at greater risk from eating these mushrooms than adults because their smaller bodies absorb proportionally more of the contaminants. Some mushroom species pose significant cancer risks from metal exposure.

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