Disease: hyperpigmentation

Antioxidant Potential-Rich Betel Leaves (Piper betle L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo

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This research shows that betel leaves, a traditional herb used in Asian cultures, can lighten skin pigmentation through multiple mechanisms. The extract works by reducing tyrosinase enzyme activity, activating cellular cleanup processes called autophagy, and boosting the body’s natural antioxidant defenses. In both laboratory cells and living mice exposed to UV radiation, betel leaves extract effectively reduced unwanted skin darkening, suggesting it could be developed into safe natural skin-whitening products.

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Anti-Melanogenic Activity of Calocedrus formosana Wood Essential Oil and Its Chemical Composition Analysis

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Researchers tested an essential oil from Taiwan’s precious Calocedrus formosana wood to see if it could lighten skin by blocking melanin production. The oil worked very well at stopping melanin synthesis in laboratory cells, with a compound called thymol being responsible for most of the lightening effect. This natural product could potentially be used in skin whitening cosmetics and offers a safer alternative to synthetic ingredients.

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Evaluation of Salvia yangii Extract as a Promising Protective Raw Material Applied Topically to the Skin

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Russian Sage (Salvia yangii) extract shows promise as a natural ingredient for skincare products. The study found that the plant contains compounds like rosmarinic acid that provide antioxidant, antimicrobial, and anti-aging benefits. When used at appropriate concentrations, the extract protected skin cells from sun damage and helped inhibit enzymes that break down skin collagen. This research supports the use of S. yangii in developing safer, more effective natural cosmetic products.

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Skin Improvement with Antioxidant Effect of Yuja (Citrus junos) Peel Fractions: Wrinkles, Moisturizing, and Whitening

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Yuja, a citrus fruit traditionally used in Asian medicine, shows promising benefits for skin health. This study found that extracts from Yuja peels can help reduce wrinkles, improve skin moisture, and lighten dark spots by protecting skin cells from UV damage and reducing harmful free radicals. The effects work through natural mechanisms that boost collagen production and inhibit melanin overproduction, making Yuja peel fractions promising ingredients for new skincare products.

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Kojic Acid Showed Consistent Inhibitory Activity on Tyrosinase from Mushroom and in Cultured B16F10 Cells Compared with Arbutins

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This study compared four skin-whitening compounds to find the best one for use as a testing standard in laboratories. Kojic acid was found to be the most reliable choice because it effectively blocks the enzyme tyrosinase, which produces skin pigment, without damaging cells. The researchers tested these compounds both in test tubes and in actual melanoma cells to understand how they work differently.

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Tyrosinase Inhibitors Derived from Chemical Constituents of Dianella ensifolia

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Researchers isolated four new plant compounds and 67 known compounds from Dianella ensifolia, a traditional Asian medicinal plant. Two of these compounds (11 and 14) were found to inhibit tyrosinase, the enzyme responsible for melanin production, making them approximately 13 times more effective than arbutin, a common cosmetic whitening ingredient. These findings suggest that D. ensifolia could be developed as a natural source of skin-whitening agents for treating age spots, freckles, and other pigmentation disorders.

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Biological and Cheminformatics Studies of Newly Designed Triazole Based Derivatives as Potent Inhibitors against Mushroom Tyrosinase

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Researchers developed new chemical compounds based on triazole structures to inhibit tyrosinase, an enzyme that produces melanin in skin. One compound (9h) proved particularly effective at blocking this enzyme, working 170 times better than the standard drug kojic acid. Computer modeling showed how this compound fits into the enzyme’s active site. These findings could lead to safer and more effective treatments for skin discoloration disorders like melasma and age spots.

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