hepatotoxicity – Page 2

Green Myco-Synthesis of Zinc Oxide Nanoparticles Using Cortinarius sp.: Hepatoprotective, Antimicrobial, and Antioxidant Potential for Biomedical Applications

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Scientists created tiny particles called zinc oxide nanoparticles using mushroom extract in an environmentally friendly way. These particles were tested and found to protect the liver from damage, kill harmful bacteria and fungi, and act as powerful antioxidants. This research suggests these mushroom-derived nanoparticles could become useful medicines for treating infections and cancer in the future.

Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin

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This research shows that Chaga mushroom extract can protect the liver from damage caused by microcystin, a toxic chemical produced by cyanobacteria in water. When mice were exposed to microcystin, their livers became damaged, but treating them with Chaga mushroom extract restored normal liver function and prevented cell death. The study suggests Chaga mushroom could be used as a natural supplement to prevent liver toxicity from environmental pollutants.

Removal of Aflatoxin B1 by Edible Mushroom-Forming Fungi and Its Mechanism

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This research discovered that edible mushroom varieties, particularly Bjerkandera adusta, can remove harmful aflatoxin B1 poison from food and animal feed. The mushroom fungi work by binding the toxin to their cell structures, acting like a sponge that soaks up the dangerous chemical. This natural method is safer and more practical than chemical or heat-based approaches because it doesn’t damage the nutritional value of food while making it safer to eat.

Inhibitive effect of Urginea epigea methanolic extract and silver/zinc oxide nanoparticles on Aspergillus and aflatoxin production

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Scientists tested a plant called Urginea epigea and special tiny particles made of silver and zinc to stop a dangerous fungus called Aspergillus flavus from growing and producing aflatoxins, which are harmful poisons found in food. When used at the right concentration, the plant extract completely stopped the fungus from growing. The treatment worked by turning off the fungus’s ability to make the poison by reducing the activity of specific genes. This natural approach could offer a safer alternative to chemical fungicides for protecting our food supply.

Educational Case: Acetaminophen hepatotoxicity: Pathophysiology and evaluation of acute liver failure

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This educational case describes how acetaminophen overdose causes severe liver damage leading to acute liver failure. The toxic form of acetaminophen damages liver cell mitochondria and causes widespread cell death, particularly in the center of liver lobules. Treatment with N-acetylcysteine within 24 hours of overdose significantly improves outcomes, though severe cases require liver transplantation.

Diversity and biological characteristics of macrofungi of district Bajaur, a remote area of Pakistan in the Hindu Kush range

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Researchers conducted the first-ever comprehensive survey of mushrooms in the Bajaur district of Pakistan, documenting 51 different species. While many species are edible and nutritious, containing high levels of protein, fiber, and minerals, some are highly poisonous and can cause serious illness or death. The study found that certain mushrooms like Morchella esculenta are already used by local communities as food and medicine, and many other species could potentially be developed for medicinal or culinary use with further research.

Pleurotus eryngii Culture Filtrate and Aqueous Extracts Alleviate Aflatoxin B1 Synthesis

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This research demonstrates that extracts from oyster mushrooms (Pleurotus eryngii) can effectively reduce dangerous aflatoxin contamination in food and feed by up to 94%. Aflatoxins are toxic compounds produced by mold fungi that can cause serious health problems including cancer. The study shows that mushroom compounds work through multiple mechanisms including antioxidant activity and enzyme production, offering a natural and environmentally friendly alternative to harmful synthetic chemicals for protecting our food supply.

Effect of Popcorn (Zea mays var. everta) Popping Mode (Microwave, Hot Oil, and Hot Air) on Fumonisins and Deoxynivalenol Contamination Levels

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This study examined how different popping methods affect harmful toxins (called mycotoxins) in popcorn. Researchers tested 39 popcorn samples using three cooking methods: hot air, hot oil, and microwave, measuring how much the dangerous toxins fumonisins and deoxynivalenol decreased. They found that all three methods reduced toxin levels, with hot oil popping being the most effective, reducing fumonisins by 98% and deoxynivalenol by 58%. These findings suggest that eating properly prepared popcorn can significantly reduce exposure to naturally occurring toxins in corn.

Disease: hepatotoxicity