hepatocellular carcinoma – Page 4

Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

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This study examined fungi in the gut of people with fatty liver disease and found that certain fungal species are more common in diseased patients. By analyzing both gut fungi and blood chemicals, researchers discovered that fungi significantly influence metabolic substances related to liver health. A computer model combining information about gut fungi and bacteria could identify fatty liver disease with reasonable accuracy, suggesting that fungi could be useful for disease diagnosis and potential treatment.

Medicinal Plants for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Antiemetic, Chemosensitizing, and Immunomodulatory Mechanisms

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This review examines how medicinal plants can help manage nausea and vomiting caused by cancer chemotherapy. Over 22 plants including ginger, cannabis, mint, and turmeric work through multiple mechanisms like blocking serotonin pathways and reducing inflammation. Beyond reducing symptoms, these plants may also enhance chemotherapy effectiveness and boost immune function. The research suggests combining medicinal plants with standard cancer treatments could improve patient outcomes and quality of life.

Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor

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This review explores how medicinal mushrooms, particularly Cerrena unicolor, can be used to improve health through functional foods and supplements. The mushroom contains natural compounds with powerful properties including fighting cancer cells, killing harmful bacteria and viruses, and protecting the body from oxidative stress. Research shows these mushrooms could be incorporated into dairy products and other foods to create innovative health-promoting products for consumers.

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications

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This research examined reishi mushroom (Ganoderma lucidum), a traditional medicinal fungus, to find rare compounds called depsidones with potential cancer-fighting properties. Scientists extracted these compounds using different solvents and tested them against four types of cancer cells (liver, colon, breast, and lung cancer), finding that they successfully killed cancer cells while being safe to normal cells. Using advanced chemical analysis and computer modeling, they identified nine new depsidone compounds in reishi and showed how these compounds could bind to cancer-related proteins to stop tumor growth.

Structure and Bioactivity of Intracellular and Extracellular Polysaccharides of Trametes lactinea Mycelium

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Researchers extracted and studied polysaccharides from Trametes lactinea mushroom mycelium grown in liquid culture. They found that these polysaccharides have strong antioxidant properties and can boost immune cell function, with the intracellular polysaccharide IP-3 showing the most promising results. These findings suggest that polysaccharides from mushroom fermentation could have potential health benefits and could be developed into medicinal supplements.

The putative forkhead transcription factor FhpA is necessary for development, aflatoxin production, and stress response in Aspergillus flavus

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Aspergillus flavus is a fungus that contaminates crops and produces aflatoxins, dangerous toxins that can harm human health and reduce crop value. Scientists studied a specific regulatory gene called fhpA that controls how this fungus develops and produces aflatoxins. They found that removing this gene causes the fungus to produce more aflatoxins and more spores but lose the ability to form protective sclerotial structures, suggesting this gene could be a target for controlling aflatoxin contamination in foods.

Unraveling the Fungi–Cancer Connection

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Fungi living in and around tumors play surprisingly important roles in cancer development and treatment response, yet they have been largely overlooked compared to bacteria. Different cancer types host specific fungal species that can promote tumor growth through immune suppression and toxin production. By better understanding and potentially targeting these tumor-associated fungi, researchers believe we could develop new combination treatments that enhance the effectiveness of existing cancer therapies.

Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

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This research reveals that the types of fungi living in our gut are linked to fatty liver disease in ways we didn’t fully understand before. While researchers have long studied bacteria in our gut, they largely ignored fungi, which turns out to play an important role too. The study found that certain fungal species are more common in people with fatty liver disease, and these fungi influence the metabolites (chemical compounds) in the blood that affect liver health. By combining information about fungi, bacteria, and blood chemistry, scientists developed a test that could identify fatty liver disease with 77% accuracy, suggesting that looking at gut fungi could help doctors diagnose and treat this common liver condition.

Proteins from Edible Mushrooms: Nutritional Role and Contribution to Well-Being

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Mushrooms are highly nutritious foods containing proteins as complete and high-quality as meat, with unique compounds that boost immunity, fight infections, and may help prevent diseases like cancer and diabetes. Different types of mushroom proteins have specific health benefits, from strengthening immune systems to lowering blood pressure and fighting viruses. Scientists are finding new ways to grow mushrooms and extract their proteins for use in sports nutrition, medicines, and fortified foods, making them increasingly valuable for human health and sustainability.

Mycotoxins: An ongoing challenge to food safety and security

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Mycotoxins are poisonous substances produced by fungi that contaminate crops and threaten both human and animal health. Climate change is making the problem worse by creating conditions that favor toxic fungi growth. Scientists are developing better detection methods and recommending integrated farming approaches to reduce contamination and protect food safety globally.

Disease: hepatocellular carcinoma