Disease: fungal nail infections

Experimental research on fungal inhibition using dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase

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Researchers developed a new patch treatment for nail fungus using tiny dissolving needles that deliver antifungal medication directly into the skin near infected nails. The patch combines two active ingredients that work together to kill fungus and break down protective biofilm layers that make fungal infections hard to treat. Testing showed the patch was safe, effective, and delivered much more medication to the infected area compared to traditional creams or pills.

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Epidemiology of Onychomycosis in the United States Characterized Using Molecular Methods, 2015–2024

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This large study examined over 710,000 nail samples to identify which fungi cause nail infections in the United States. Using modern molecular testing combined with microscopic analysis, researchers found that while the fungus T. rubrum is most common, other molds and yeasts cause many infections too. Importantly, women and older adults are more likely to have infections from these other organisms, which are often harder to treat with standard antifungal medications.

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Safety and efficacy of the swift microwave device in patients with mild-to-moderate onychomycosis: Protocol of an open-label, randomized, dose-finding pilot study

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This study evaluates a new microwave device (Swift System) as a potential treatment for fungal nail infections (onychomycosis). The device uses microwave energy to heat and eliminate fungal infections directly at the nail site, avoiding the side effects of oral medications. Researchers tested three different treatment schedules in 39 patients over 12 months to find the most effective dosing approach.

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The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum

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Researchers discovered that a protein called TrPtk2 helps dermatophytes resist terbinafine, a common antifungal medicine. They found that blocking this protein makes the fungus more susceptible to terbinafine. Additionally, they discovered that omeprazole, a stomach medication approved for human use, can be combined with terbinafine to make it more effective against resistant fungal infections.

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