fungal infections – Page 12

Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens

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Researchers discovered that hydrogen sulphide (H2S), a small gas molecule, can effectively kill the fungi and bacteria that cause painful nail infections. Unlike current treatments that struggle to penetrate into the nail, hydrogen sulphide easily diffuses through the nail plate. The study found that H2S works by damaging the fungi’s respiratory system and creating harmful reactive oxygen species, while also modifying proteins in a way that disrupts their normal function. This innovative approach could offer patients a new topical treatment option for nail infections that have been difficult to treat with existing medications.

Antifungal effect of soil Bacillus bacteria on pathogenic species of the fungal genera Aspergillus and Trichophyton

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Researchers found that certain bacteria called Bacillus, naturally occurring in soil, can effectively kill dangerous fungi that cause infections in humans. These bacteria produce compounds that are as effective or more effective than standard antifungal medications. This discovery could lead to new treatments for fungal infections, especially as fungi increasingly develop resistance to current drugs.

Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan

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Candida albicans is a fungus that causes infections in humans. The fungus has developed a clever way to hide from our immune system by covering up a molecule on its surface called β-1,3-glucan that normally triggers immune responses. This study shows that the fungus masks this molecule through a combination of growing and dividing to create new surfaces, and then using enzymes to trim away exposed molecules. The research reveals that a specific cell signaling pathway controlled by lactate (a chemical found in our bodies) activates this masking behavior, helping the fungus evade immune recognition.

Corrigendum: Navigating the fungal battlefield: cysteine-rich antifungal proteins and peptides from Eurotiales

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This article provides a correction to previously published research about special proteins and peptides produced by certain fungi that can fight other fungal infections. The corrections involve fixing errors in a table that listed important chemical properties of these antifungal molecules. These molecules come from various Penicillium and Aspergillus fungal species and could potentially be used to develop new antifungal treatments.

Reevaluating the Value of (1,3)-β-D-Glucan for the Diagnosis of Intra-Abdominal Candidiasis in Critically Ill Patients: Current Evidence and Future Directions

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This review examines how a fungal biomarker called beta-D-glucan (BDG) can help doctors diagnose yeast infections in the abdomens of critically ill patients. While BDG tests in the blood are available, they give many false positives. Testing BDG directly in fluid from the abdomen appears more accurate, especially when combined with blood tests. However, more research is needed before hospitals widely adopt this approach in daily practice.

Antifungal effect of soil Bacillus bacteria on pathogenic species of the fungal genera Aspergillus and Trichophyton

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Researchers discovered that four types of Bacillus bacteria found in soil can effectively kill dangerous fungi that cause infections in humans. These bacteria produce natural compounds that inhibit fungal growth even better than some standard antifungal medications. This discovery is particularly important because many fungi are becoming resistant to current drugs, making these soil bacteria a promising natural alternative for treating fungal infections.

Antagonistic Potential of Agro-Industrial Byproduct–Derived Lactic Acid Bacteria Against Mycotoxigenic Aspergillus flavus and Fusarium verticillioides

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Researchers discovered that certain lactic acid bacteria found in food waste products can effectively prevent the growth of harmful fungi and block the production of dangerous mycotoxins. These bacteria work through multiple mechanisms including acidification and production of protective compounds. The findings suggest these natural bacteria could be used as safe, sustainable alternatives to chemical fungicides in food preservation and safety.

Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities

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Researchers extracted and identified six chemical compounds from A. blazei mushrooms and tested their ability to fight fungal infections. The compounds showed promising activity against common fungal pathogens that cause infections in humans. This research suggests that A. blazei could be developed into natural antifungal treatments. The findings add to growing evidence that medicinal mushrooms contain valuable bioactive compounds with therapeutic potential.

Deep learning application to hyphae and spores identification in fungal fluorescence images

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Researchers developed an artificial intelligence system using two deep learning models to automatically identify fungal infections in microscope images. The system analyzes fluorescence-stained samples to detect fungal spores, hyphae, and mycelium with accuracy matching experienced doctors. This automated approach can significantly reduce the time clinicians spend examining samples and help prevent misdiagnosis, especially in hospitals with fewer specialist technicians.

Natural Antimicrobial Compounds as Promising Preservatives: A Look at an Old Problem from New Perspectives

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This review examines natural alternatives to synthetic food preservatives, which are increasingly recognized as potentially harmful. Natural antimicrobial compounds from plants, fungi, and other sources can effectively prevent food spoilage and bacterial contamination. New technologies using light and ultrasound can enhance these natural compounds’ effectiveness. While promising, these natural preservatives need more research and regulatory approval before widespread industrial use.

Disease: fungal infections