Disease: fatigue

Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial

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Researchers conducted a small pilot study examining whether psilocybin (the active compound in certain mushrooms) combined with therapy could help treat fibromyalgia, a chronic pain condition. Five participants received two doses of psilocybin along with supportive therapy sessions. The treatment was well-tolerated with only minor side effects, and participants reported significant improvements in pain, sleep quality, and overall functioning. These promising preliminary results suggest larger studies should be conducted to further test this innovative treatment approach.

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Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models

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Enokitake mushrooms and their active compound adenosine can boost testosterone production in mice experiencing fatigue and aging-related decline. The study shows that consuming adenosine-rich mushrooms may help restore testicular function and provide anti-aging benefits. This finding suggests that commonly available edible mushrooms like enokitake could be a natural functional food for managing fatigue and age-related hormone decline. However, human studies are needed to confirm these effects.

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The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts

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Different recipes made from Ganoderma lucidum mushroom have different health benefits. This study tested two recipes in mice and found that one (PGB) was better for reducing fatigue and improving exercise performance, while the other (GBS) was better for improving sleep quality. The research shows that how you prepare and combine medicinal mushroom ingredients matters for what health benefits you get.

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Isolation, identification and antibacterial activity of endophytes from the seeds of Panax japonicus

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This study investigated microscopic organisms living inside Panax japonicus seeds to understand why these seeds are difficult to grow. Researchers found the best way to clean the seeds and identified ten different microorganism species living in them. Most of these were fungi that may actually prevent seed germination, while certain bacteria species appear beneficial for plant growth and could potentially be used to improve seed cultivation in the future.

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Isolation, identification and antibacterial activity of endophytes from the seeds of Panax japonicus

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Researchers isolated and identified 10 different microorganisms (7 fungi and 3 bacteria) living inside Panax japonicus seeds. They found that a specific type of bacteria (Enterobacteriaceae and Pseudomonas) may help promote seed growth, while certain fungi may inhibit it. The study also determined the best way to sterilize seeds before experimentation, which is important for studying plant propagation of this valuable medicinal herb.

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Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress

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Researchers successfully sequenced the complete genome of Cordyceps militaris CH1, a medicinal fungus used in traditional Chinese medicine. By exposing the fungus to light and analyzing gene expression and metabolite changes, they discovered that light stress activates key genes involved in producing cordycepin, the main active medicinal compound. This breakthrough provides a foundation for improving cordycepin production in artificial cultivation, making this valuable medicine more affordable and accessible.

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