Epilepsy – mycolab.ai

Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ- and MES-Induced Seizures in Mice via 5-HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways

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Researchers tested psilocin, the active ingredient in magic mushrooms, and found it could reduce seizures in mice at low doses (3-5 mg/kg) without causing psychedelic effects. The anticonvulsant benefits were mediated through several brain pathways including serotonin, cannabinoid, opioid, and nitric oxide signaling systems. The effects persisted for at least 9 days after a single dose, suggesting psilocin may have potential as a new treatment for epilepsy, though human clinical trials are needed to confirm these findings.

Medicinal Mushrooms as Multicomponent Mixtures—Demonstrated with the Example of Lentinula edodes

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Shiitake mushrooms are more than just tasty food—they contain numerous compounds that work together to improve health. Unlike single isolated drugs, whole mushroom preparations offer multiple benefits including boosting immunity, protecting the heart, and potentially supporting cancer treatment. These mushrooms have been used safely in Asian medicine for over 2000 years and are becoming recognized worldwide for their health-promoting properties.

Innovative Bioactive Nanofibrous Materials Combining Medicinal and Aromatic Plant Extracts and Electrospinning Method

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This research explains how scientists use a technique called electrospinning to create tiny, beneficial fibers from medicinal plants. By combining plant extracts like turmeric with biodegradable polymers, researchers create advanced materials that can deliver medicine, promote wound healing, and fight bacteria. These innovative fibers represent a natural approach to healthcare, bringing ancient plant wisdom into modern nanotechnology for practical medical applications.

Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models

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Scientists studied a gene called CAPZA2 that helps control how brain cells connect to each other. When this gene doesn’t work properly, mice had trouble learning, remembering things, and interacting socially, similar to intellectual disability in humans. The researchers found that the problem happens because the connections between brain cells become abnormal and don’t mature properly. This research helps explain why some people with mutations in this gene have developmental difficulties and could lead to new treatments.

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

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ELAV/Hu proteins are molecular machines that control how cells read and use genetic instructions. Found mostly in the brain and nervous system, these proteins help manage which genes get turned on or off, which is crucial for proper brain development and function. When these proteins go wrong, they can contribute to serious diseases like Alzheimer’s, Parkinson’s, cancer, and autism, making them promising targets for new treatments.

A Case of Pulmonary Infection Due to Magnusiomyces capitatus in a Non-Immunocompromised Patient with Cerebral Palsy

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A young man with cerebral palsy developed a rare lung infection caused by Magnusiomyces capitatus, a fungus that usually only affects people with weakened immune systems. Doctors diagnosed the infection by analyzing fluid from his lungs and identified the fungus using advanced laboratory techniques. The patient improved after being treated with an antifungal medication called voriconazole. This case highlights that this rare fungal infection can occur in otherwise healthy people, especially those with conditions affecting their ability to clear lung secretions.

Disease: Epilepsy

Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ- and MES-Induced Seizures in Mice via 5-HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways

Medicinal Mushrooms as Multicomponent Mixtures—Demonstrated with the Example of Lentinula edodes

Innovative Bioactive Nanofibrous Materials Combining Medicinal and Aromatic Plant Extracts and Electrospinning Method

Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

A Case of Pulmonary Infection Due to Magnusiomyces capitatus in a Non-Immunocompromised Patient with Cerebral Palsy