Disease: ephelides

Development of dihydrooxyresveratrol-loaded nanostructured lipid carriers for safe and effective treatment of hyperpigmentation

This research developed a new skin-brightening treatment using nanoparticles to deliver oxyresveratrol and its modified form (DHO) more effectively to the skin. The scientists improved the stability of these compounds by creating tiny lipid-based carriers that protect them from light damage and help them penetrate the skin barrier. Testing showed these formulations safely reduced melanin production without harming healthy skin cells, offering promise for cosmetic products to treat dark spots and hyperpigmentation.

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Tyrosinase Inhibitors Derived from Chemical Constituents of Dianella ensifolia

Researchers isolated four new plant compounds and 67 known compounds from Dianella ensifolia, a traditional Asian medicinal plant. Two of these compounds (11 and 14) were found to inhibit tyrosinase, the enzyme responsible for melanin production, making them approximately 13 times more effective than arbutin, a common cosmetic whitening ingredient. These findings suggest that D. ensifolia could be developed as a natural source of skin-whitening agents for treating age spots, freckles, and other pigmentation disorders.

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