Endocarditis – mycolab.ai

Antibacterial and Antifungal Activity and Acute Toxicity of Crude Extracts From the Wild Edible Mushrooms Cantharellus veraecrucis, Cantharellus violaceovinosus, and Turbinellus floccosus

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Researchers tested extracts from three wild edible mushroom species found in Mexican forests for their ability to fight harmful bacteria and fungi. The extracts showed promise against disease-causing microorganisms, with one species particularly effective against agricultural plant pathogens. While the extracts showed moderate toxicity at high doses, the results suggest these mushrooms could be developed into natural pesticides or medicines.

Addressing Critical Fungal Pathogens Under a One Health Perspective: Key Insights from the Portuguese Association of Medical Mycology

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Four dangerous fungal species pose growing threats to human health worldwide, especially for people with weakened immune systems. Portugal’s medical experts have reviewed the current situation, finding these fungi increasingly resistant to treatment, present in hospitals and the environment, and occasionally spreading from animals to people. The review emphasizes the need for better testing, coordinated tracking systems, and approaches that consider human, animal, and environmental health together to combat this emerging crisis.

Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey

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This study examined 73 patients in Turkey who developed bone and joint infections caused by Candida fungi over ten years. The researchers found that diabetes was very common among patients and made recovery harder, while surgery to clean out infected tissue significantly improved outcomes. Importantly, they discovered resistance to common antifungal medications was higher in certain Candida species compared to others.

Closing the diagnostic gap in medical mycology: The LODDY Test for identification of Lodderomyces elongisporus

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Researchers developed a simple and affordable test called the LODDY Test to identify a dangerous yeast called Lodderomyces elongisporus that is often mistaken for a similar but less dangerous yeast. This test uses color changes on a special culture medium to distinguish between different yeast species in just 48 hours without expensive equipment. The test works perfectly in laboratories worldwide and could help doctors in developing countries diagnose and treat serious fungal infections more quickly and accurately.

Successful Management of Spondylodiscitis Caused by Aspergillus nidulans: A Case Report and Literature Review

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A 59-year-old patient with lymphoma developed a serious fungal spine infection caused by Aspergillus nidulans, a rare mold. The infection was diagnosed using imaging, fungal cultures, and laboratory testing. The patient was successfully treated with a 6-month course of the antifungal drug voriconazole without requiring surgery. This case is notable because it represents the first successful treatment of this extremely rare infection in a cancer patient.

Candida blankii: The Difficult Capture of a Fungus With Pathogenic Potential

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Candida blankii is a rare fungal pathogen that is increasingly being found in hospital patients’ bloodstreams and respiratory tracts. The organism is difficult to identify using standard laboratory tests, which can delay diagnosis and treatment. This case report describes two adult patients with C. blankii infections and highlights the challenges in identifying this emerging pathogen and its resistance to common antifungal medications.

Changing Climate, Changing Candida: Environmental and Social Pressures on Invasive Candidiasis and Antifungal Resistance in Latin America

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Invasive fungal infections caused by Candida yeasts are becoming more serious in Latin America, with drug-resistant strains spreading rapidly in hospitals. The problem is worsened by climate change and overuse of antifungal medicines in agriculture, which help resistant fungi survive and spread. Many hospitals in the region lack modern diagnostic tools to quickly identify the specific type of infection, delaying treatment. The authors recommend a comprehensive approach combining better environmental monitoring, smarter use of antifungal drugs, improved diagnostic access, and coordinated public health efforts across the region.

Taxonomic revision of Bisifusarium (Nectriaceae)

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Scientists have identified and formally named 8 new species of Bisifusarium, a genus of fungi found in cheese, soil, and some human infections. Using genetic analysis and careful observation of fungal structures, researchers studied 116 fungal samples collected from around the world. This work more than doubled the known number of Bisifusarium species from 16 to over 24, providing clearer identification methods for future research in food science and medicine.

Endocarditis caused by Scopulariopsis brevicaulis with disseminated emboli and multiple vascular aneurysms: A case report and literature review

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A 61-year-old man with a prosthetic aortic valve developed a rare fungal infection caused by Scopulariopsis brevicaulis, a mold usually associated with nail infections. The infection spread throughout his body, causing multiple strokes and aneurysms that required emergency surgery and treatment with various antifungal medications. This case highlights the serious complications that can occur when this typically harmless fungus invades the heart and demonstrates the challenges doctors face in treating such rare infections, as the fungus was resistant to many common antifungal drugs.

Invasive fungal infections caused by rare yeast-like fungi in adult patients: results of a prospective study

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This study examined rare fungal infections in 30 critically ill adult patients over 18 years, finding that infections caused by uncommon yeasts like Trichosporon and Rhodotorula affected mainly long-term ICU patients with central lines. Despite treatment with antifungal medications, about 37% of patients died, highlighting the serious nature of these infections. The research emphasizes the importance of quickly identifying the specific fungus causing infection and using appropriate medications, along with removing infected catheters, to improve patient survival.

Disease: Endocarditis