Disease: dysbiosis

Dietary melanoidins as emerging functional components: interactions with gut microbiota and implications for nutritional modulation of intestinal health

Melanoidins are natural brown compounds formed when foods are cooked or fermented, found in items like roasted coffee, bread, and soy sauce. When eaten, these compounds pass through the stomach and small intestine unchanged, then are broken down by beneficial bacteria in the colon. This breakdown produces helpful substances that support gut health, reduce inflammation, and may help prevent digestive diseases like irritable bowel syndrome and inflammatory bowel disease.

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Bioactive Peptides from Quinoa (Chenopodium quinoa Willd.) as Modulators of the Gut Microbiome: A Scoping Review of Preclinical Evidence

This review examines how quinoa and its protein-derived peptides can improve gut health by changing the balance of bacteria in the digestive system. Research shows that quinoa helps boost beneficial bacteria, increases diversity of microbial communities, and promotes production of butyrate, a beneficial compound that supports intestinal health. Different disease conditions show specific improvements, such as reduced harmful bacteria in colitis and better metabolic balance in obesity, suggesting quinoa could be tailored for personalized health interventions.

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Fungal β-Glucans Enhance Lactic Acid Bacteria Growth by Shortening Their Lag Phase and Increasing Growth Rate

Researchers tested whether extracts from common edible mushrooms like oyster and shiitake could help beneficial bacteria in the gut grow better. They found that these mushroom extracts, particularly their β-glucan components, helped probiotic bacteria start growing faster and grow more quickly. Importantly, the extracts did not help harmful bacteria grow, making them promising candidates for developing healthier food supplements that support gut health.

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Whey Proteins and Bioactive Peptides: Advances in Production, Selection and Bioactivity Profiling

Whey, a liquid byproduct from cheese-making that was once considered waste, contains valuable proteins that can be broken down into smaller bioactive peptides. These peptides have numerous health benefits including antimicrobial, anti-inflammatory, and antioxidant properties, and can be used in functional foods and medicines. Researchers are developing advanced techniques to extract and produce these peptides more efficiently, and using computer models to predict which peptides will have specific health benefits.

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Nutraceutical supplement slim reshaped colon histomorphology and reduces Mucispirillum schaedleri in obese mice

Researchers tested a supplement called Slim containing natural compounds like berberine, coenzyme Q10, and beet pulp on obese mice. After 4 weeks, the supplement improved cholesterol and triglyceride levels, increased beneficial gut bacteria, and strengthened the intestinal barrier. The results suggest this combination of natural ingredients works together synergistically to improve gut health and metabolic function in obesity.

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The Hidden Microbial World in the Gut of the Terrestrial Snail Cornu aspersum maxima and the Unexpected Negative Effects of Synbiotics

This study tested whether adding beneficial bacteria (probiotics) and dietary fibers (prebiotics) to snail farm feed could improve snail health and growth. While individual probiotic and prebiotic treatments helped reduce harmful bacteria in snails’ digestive systems, combining them together as a synbiotic surprisingly caused extremely high death rates in the snails. The results show that more research is needed before combining these supplements in snail farming.

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Koumiss (Fermented Mare’s Milk) as a Functional Food: Bioactive Proteins, Peptides, and Future Perspectives

Koumiss is a fermented mare’s milk beverage consumed for centuries in Central Asia that offers unique health benefits. Unlike cow’s milk, mare’s milk is easier to digest, contains natural antimicrobial proteins, and when fermented develops thousands of bioactive peptides and beneficial bacteria. These compounds may help with cardiovascular health, gut function, and immune support, making koumiss a promising functional food for modern nutrition.

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Nanoencapsulation of Biotics: Feasibility to Enhance Stability and Delivery for Improved Gut Health

This review explores how tiny nanoparticles can protect beneficial bacteria and dietary compounds as they travel through the digestive system. These nanotechnologies help probiotics survive stomach acid and reach the intestines where they provide health benefits. The research shows promising results for treating digestive diseases and improving overall gut health through better delivery of microbiota-modulating substances.

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Potential Roles of Exogenous Proteases and Lipases as Prebiotics

This review explores how digestive enzymes like proteases and lipases work similarly to prebiotics—foods that feed beneficial bacteria in your gut. When animals consumed supplements of these enzymes, their gut bacteria became healthier, producing more beneficial compounds and showing improved intestinal health. These findings suggest that fermented foods and raw foods containing natural digestive enzymes, as well as enzyme supplements, may help promote a healthy gut microbiome.

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Investigating the Knowledge of Prebiotics, Probiotics, and Synbiotics That May Help to Improve the Gut-Organ Axis Function in Middle-Aged and Older Adults

This study examined what middle-aged and older adults know about probiotics, prebiotics, and synbiotics—special food components that can improve gut health. Researchers found that many people had little knowledge about these products, even though they may help with various health conditions including heart disease and mental health. After giving people an educational information sheet about gut biotics, their knowledge significantly improved, suggesting that simple education can help people make better choices about their digestive health.

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