Disease: drug-induced liver injury

Development and preliminary mechanistic analysis of compound effervescent hepatoprotective granules

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Researchers developed a new health product combining three medicinal plants to protect the liver from injury. The mixture contains effective compounds that reduce liver inflammation, fight harmful oxidative stress, and protect liver cells from damage. Studies in rats showed the product improved liver function and reduced markers of liver damage, suggesting it could be useful for preventing and treating liver injuries caused by drugs, alcohol, or toxins.

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Educational Case: Acetaminophen hepatotoxicity: Pathophysiology and evaluation of acute liver failure

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This educational case describes how acetaminophen overdose causes severe liver damage leading to acute liver failure. The toxic form of acetaminophen damages liver cell mitochondria and causes widespread cell death, particularly in the center of liver lobules. Treatment with N-acetylcysteine within 24 hours of overdose significantly improves outcomes, though severe cases require liver transplantation.

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Herbal Supplement-Induced Liver Injury: A Case Report

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A 45-year-old woman developed severe liver injury after drinking an herbal tea containing multiple ingredients, including reishi mushroom and aloe vera. Her liver function gradually improved after she stopped drinking the tea, with complete recovery within three months. This case demonstrates that herbal supplements, often perceived as safe, can cause serious liver damage and should be investigated when patients develop unexplained liver problems.

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Therapeutic Plasma Exchange in Acute Liver Failure: A Real-World Study in Mexico

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Acute liver failure is a serious medical emergency where the liver suddenly stops working properly. This study found that a treatment called therapeutic plasma exchange (TPE), which filters the blood to remove harmful substances, significantly improved survival rates in liver failure patients treated in a Mexican hospital. Patients receiving TPE had a 92% survival rate at 30 days compared to only 50% in those receiving standard treatment alone, even though the TPE group had more severe cases at the start.

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