Disease: Disseminated mycosis

Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen

A 65-year-old woman who received a lung transplant developed a rare and serious brain infection caused by an unusual fungus called Rasamsonia argillacea. The infection was difficult to diagnose because it looks similar to more common molds under the microscope. During the investigation of this unexpected infection, doctors discovered that the patient had a rare genetic disorder affecting her immune system that had never been diagnosed. This case highlights how unusual infections can reveal hidden immune system problems.

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Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child

A young girl contracted a dangerous drug-resistant fungal infection in her knee after an injury, which failed to respond to standard antifungal treatments. Doctors obtained special access to an experimental antifungal drug called olorofim through a compassionate use program. The child showed improvement within two weeks and was completely cured after six months of treatment with no signs of the infection returning two years later, making this the first successful case of this new drug being used in a child.

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Infection caused by a cryptic fungal species, Blastomyces gilchristii, in a tiger

A tiger at a veterinary hospital developed a serious fungal infection that affected its brain and lungs. Using advanced DNA sequencing technology, researchers identified the infection was caused by a previously unrecognized fungal species called Blastomyces gilchristii. This discovery was important because it showed that this dangerous fungus exists in areas where scientists previously thought it wasn’t found, and it highlights the importance of using modern genetic testing to identify unusual infections.

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Infection caused by a cryptic fungal species, Blastomyces gilchristii, in a tiger

A tiger in Tennessee became ill with a serious fungal infection caused by a lesser-known fungus called Blastomyces gilchristii. While blastomycosis is typically caused by a different fungus species, this case represents the first detection of this particular cryptic fungal species in the southeastern United States. Scientists used advanced genetic sequencing to identify the fungus when standard laboratory methods failed. This discovery suggests that this dangerous fungus is spreading to areas where it was not previously thought to exist.

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