Disease: Disseminated infection

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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This study reviews how well a molecular test called PCR can diagnose mucormycosis, a dangerous fungal infection. Researchers analyzed 30 studies covering over 5,000 patient samples and found that PCR works very well for detecting this infection, especially when using samples from the lungs. Blood tests were also effective but slightly less sensitive. The study recommends using PCR as part of updated diagnostic guidelines to help doctors catch this serious infection earlier, potentially improving patient outcomes.

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Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

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Researchers developed and tested a new rapid test (TG11-LFD) for detecting mucormycosis, a dangerous fungal infection, using a simple device similar to a COVID rapid test. The test detects a specific protein marker released by Mucorales fungi in lung fluid samples. In testing with 62 clinical samples, the new test correctly identified about 77% of actual infections and was negative in about 76% of non-infected samples. This affordable, simple test could help doctors quickly diagnose mucormycosis and start life-saving treatment faster, especially in countries with limited laboratory resources.

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