Disease: Disseminated histoplasmosis

Shared Vision for Improving Outcomes for Serious Fungal Diseases: Report of a Patient, Caregiver, and Clinician Summit

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Patients with serious fungal infections face significant challenges including long delays before diagnosis, substantial emotional and financial burden, and lasting effects on quality of life. A summit brought together patients, their caregivers, and fungal disease experts to share experiences and identify priorities for improving care. The group identified needs for better diagnostic tools, new treatments, improved medical education about fungal diseases, and patient support programs to help future patients and their families navigate fungal infections more effectively.

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Photo Quiz: A cutaneous fungal infection with discordant biomarker results—a diagnostic challenge

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A woman with advanced HIV disease presented with unusual skin lesions that were initially suspected to be from a virus, but laboratory testing revealed a rare fungal infection called histoplasmosis caused by Histoplasma capsulatum. The case was challenging because some standard fungal tests came back negative even though the patient had the infection, showing why doctors need to rely on culture and examination under the microscope. She was treated with antifungal medications and her diagnosis highlights the importance of considering fungal infections in severely immunocompromised patients even when initial tests seem negative.

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Usefulness of Serum as a Non-Invasive Sample for the Detection of Histoplasma capsulatum Infections: Retrospective Comparative Analysis of Different Diagnostic Techniques and Quantification of Host Biomarkers

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This study evaluated how well different blood tests can detect histoplasmosis, a serious fungal infection caused by Histoplasma capsulatum. Researchers compared three types of tests: those detecting fungal antigens, those detecting antibodies the body produces against the fungus, and DNA-based tests. They found that the best test depends on whether the patient’s immune system is functioning normally or is weakened by HIV, and using a combination of tests provides the most reliable diagnosis. The study also identified specific immune markers in the blood that are elevated in infected patients, which could help predict disease severity.

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