Disease: disseminated disease

Impact of glycemic control on coccidioidomycosis outcomes in patients with underlying diabetes mellitus in central California

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This study examined how blood sugar control affects outcomes in patients with both diabetes and coccidioidomycosis, a fungal infection common in central California. Researchers found that patients with poorly controlled diabetes (higher HbA1c levels) had higher rates of serious lung disease with cavities and were less likely to recover from the infection. The study highlights that managing blood sugar levels may be just as important as taking antifungal medications when treating this dual condition.

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The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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This study evaluated how well PCR blood tests and tissue samples can diagnose a serious fungal infection called mucormycosis. Researchers analyzed 30 previous studies and found that PCR testing works very well, especially on respiratory fluid samples. Blood tests showed good accuracy too and could be useful for screening high-risk patients without requiring invasive procedures. The findings suggest PCR should become a standard diagnostic method for this difficult-to-diagnose infection.

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Identification of Non-fumigatus Aspergillus Species in Clinical Samples from Southern California

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Researchers in Southern California studied fungal infections caused by Aspergillus, a common mold that can infect humans. They found that species other than the traditionally dangerous A. fumigatus are now being detected more frequently in patient samples, particularly from skin and respiratory infections. These non-fumigatus species showed interesting seasonal patterns and some may be resistant to standard antifungal treatments, suggesting doctors may need to adjust their treatment strategies.

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