dementia – Page 2 – mycolab.ai

Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer’s Disease Model Mice and the SH-SY5Y Neuronal Cell Line

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Researchers tested a probiotic supplement called Lab4P on mice genetically engineered to develop Alzheimer’s-like symptoms and on human brain cells exposed to damaging proteins. The supplement successfully improved memory and cognitive function in the mice while protecting brain cells from damage, with stronger benefits when the mice were also on a high-fat diet. These findings suggest that probiotics might help prevent or slow cognitive decline related to Alzheimer’s disease.

Microbial links to Alzheimer’s disease

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Researchers are investigating whether common infections from bacteria, viruses, and fungi might trigger or worsen Alzheimer’s disease. Studies show that pathogens like the bacteria that causes gum disease and certain herpes viruses can reach the brain and trigger inflammation and amyloid-beta accumulation, key features of Alzheimer’s. While the evidence is promising, scientists haven’t yet proven whether these infections cause Alzheimer’s or simply make existing disease worse.

Association of mushroom consumption with all-cause and cause-specific mortality among American adults: prospective cohort study findings from NHANES III

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This study followed over 15,000 American adults for nearly 20 years and found that people who ate mushrooms had a lower risk of dying from any cause compared to those who didn’t eat mushrooms. The more mushrooms people ate, the greater the benefit. Replacing red or processed meat with mushrooms was associated with even greater longevity benefits. Mushrooms’ beneficial effects likely come from their high antioxidant content, particularly compounds called ergothioneine and glutathione.

Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review

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Lion’s Mane mushroom shows promising benefits for brain health, potentially improving memory and reducing symptoms of anxiety and depression. It may help prevent cancer by triggering cancer cell death and supports digestive health by promoting beneficial gut bacteria. While generally safe, some people experience mild side effects like stomach discomfort or headaches, making it an accessible supplement for overall wellness.

N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer’s disease

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This research reveals how an abnormal RNA molecule called circRIMS2 contributes to Alzheimer’s disease by damaging brain synapses and impairing memory. Scientists found that circRIMS2 levels are elevated through a chemical modification called m6A methylation, and this causes a cascade of events leading to the destruction of important proteins needed for brain communication. The study shows that blocking this damaging pathway using a specially designed peptide can restore memory and synaptic function in Alzheimer’s disease models, offering hope for new therapeutic approaches.

Microbial links to Alzheimer’s disease

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This review examines whether germs like bacteria, fungi, and viruses might play a role in causing Alzheimer’s disease. Scientists have found that certain bacteria from the mouth and gut, fungal infections, and cold sores (herpes viruses) appear more frequently in Alzheimer’s patients and may trigger the brain changes that damage memory and thinking. While the evidence is promising, researchers still need to determine whether these infections actually cause Alzheimer’s or simply make it worse once it develops.

Correlation between Vegetable and Fruit Intake and Cognitive Function in Older Adults: A Cross-Sectional Study in Chongqing, China

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This study examined how eating different types of fruits and vegetables affects brain health in older adults in Chongqing, China. Researchers found that higher fruit intake and eating more root vegetables (like carrots and turnips) were associated with better cognitive function and lower risk of mild cognitive impairment. Some vegetables like tomatoes and peppers also showed protective benefits, while leafy greens did not show a significant effect. The findings suggest that encouraging older adults to eat more fruits and certain vegetables could help prevent memory problems and cognitive decline.

Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy

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Researchers used advanced microscopy techniques to examine brain tissue from rats with Alzheimer’s disease and compared it to healthy rats. They found that Alzheimer’s disease causes damage to connections between brain cells (synapses) in a brain region important for thinking and memory. Specifically, the connections were weaker and smaller, and many new spine-like structures formed but didn’t properly connect to other cells, suggesting the brain may be trying unsuccessfully to compensate for the disease.

Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease

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Scientists studied how Bcl-2 proteins might protect the brain from Alzheimer’s disease by controlling calcium levels in nerve cells. They injected modified Bcl-2 proteins into the brains of mice engineered to develop Alzheimer’s symptoms and found that these proteins helped preserve the connections between nerve cells and reduced harmful amyloid plaque buildup. A special version of Bcl-2 that worked primarily on one type of calcium channel was surprisingly most effective at reducing amyloid plaques, suggesting this specific mechanism could be important for treating Alzheimer’s disease.

Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction

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This study found that regular exercise helps protect the brain of diabetic people from cognitive decline by boosting a protein called NDRG2 in astrocytes (brain support cells). The research shows that NDRG2 works by blocking harmful immune responses that damage synapses (connections between brain cells). In diabetic mice, exercise improved memory and learning ability while increasing NDRG2 levels, while blocking this protein reversed these benefits.

Disease: dementia