This review examines two important protein complexes in fungal cells that help control which genes are turned on and off. These complexes, called SWI/SNF and RSC, use energy from ATP to move and adjust nucleosomes—the structures that package DNA. The researchers analyzed these complexes across different fungal species and found that while they share similar core components, fungi have evolved unique variations that allow them to survive and cause infections in different ways. Understanding how these complexes work could help scientists develop new antifungal drugs.