Cognitive decline – mycolab.ai

(Poly)phenol-gut microbiota interactions and their impact on human health

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Plant-based foods rich in polyphenols like berries, tea, and cocoa offer significant health benefits through interactions with gut bacteria. These bacteria break down polyphenols into active compounds that can help prevent heart disease, diabetes, and cancer. However, people respond differently to these foods based on their unique gut bacteria composition, suggesting the future of nutrition will be personalized based on individual microbial profiles.

Assessment of Heavy Metals in Mexican Dietary Supplements Using Total X-Ray Fluorescence Spectrometry and Health Risk Evaluation

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Mexican dietary supplements commonly contain toxic heavy metals like lead, arsenic, and chromium. While individual metal levels in most supplements appeared safe when consumed alone, the cumulative exposure from multiple metals could increase cancer risk over a lifetime. The study found that some popular supplements, particularly those marketed for weight loss and blood detoxification, contained concerning metal levels, especially seaweed-based products and animal-origin supplements. Better regulation and labeling of dietary supplements in Mexico is urgently needed to protect consumers from long-term health risks.

Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery

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Scientists created a new type of yogurt that contains beneficial bacteria and special prebiotics from rice straw. The innovation uses tiny nanoparticles to protect some of the prebiotics so they reach your gut intact, while free prebiotics immediately feed the beneficial bacteria in the yogurt during storage. This dual-delivery approach keeps the yogurt fresher longer while ensuring you get maximum health benefits for your digestive system.

Ergothioneine: An Antioxidative, Neuroprotective and Anti-Inflammatory Compound from Mushroom Residuals

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Ergothioneine is a powerful antioxidant found mainly in mushrooms that protects brain health and reduces inflammation. Mushroom processing creates large amounts of waste like stems and leftover substrate that actually contain high levels of this beneficial compound. Scientists have developed sustainable methods to extract ergothioneine from this waste, creating opportunities for new health supplements and functional foods while reducing waste and supporting environmental sustainability.

Safety, feasibility, and tolerability of psilocybin in older adults with amnestic MCI: Preliminary data from a SV2a PET imaging study

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Researchers investigated whether psilocybin, a compound from certain mushrooms, could be safely used to treat memory problems in older adults with mild cognitive impairment. In this early-stage study, participants received either psilocybin or a placebo while researchers used brain imaging to measure changes in synaptic connections. The preliminary results suggest psilocybin was well-tolerated with manageable side effects like dizziness, and participants were able to complete the study without serious problems.

Soil microorganism colonization influenced the growth and secondary metabolite accumulation of Bletilla striata (Thunb.) Rchb. F.

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Chinese ground orchid (Bletilla striata) is a medicinal plant whose growth and medicinal compound production depend heavily on soil microorganisms. Researchers found that different soil types harbor different beneficial microbes: sandy loam soils boost plant growth, while sandy clay soils increase medicinal compound concentration. Specific microbes colonize different plant parts, with some promoting growth in roots and tubers, while others enhance the production of militarine, a compound with potential anti-aging and cognitive benefits.

Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models

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This research shows that overweight and obese individuals have higher levels of a toxic compound called quinolinic acid in their bodies, which is linked to memory problems and brain shrinkage. The good news is that butyrate, a substance naturally produced by gut bacteria when we eat fiber, can protect against these harmful effects. Butyrate works by activating genes that produce brain-derived neurotrophic factor (BDNF), a protein essential for brain health and memory formation. The study suggests that increasing butyrate through diet or supplements could help prevent cognitive decline associated with obesity.

Innovative applications of medicinal mushrooms in functional foods and nutraceuticals: a focus on health-boosting beverages

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This comprehensive review explores how medicinal mushrooms are being transformed into health-boosting beverages like coffees, teas, and energy drinks. Mushrooms contain powerful compounds that support immunity, reduce inflammation, protect the liver, and enhance brain function. As consumers increasingly seek natural health alternatives, mushroom beverages are emerging as a major market trend, combining ancient wellness traditions with modern science to create convenient, tasty drinks that genuinely benefit health.

Correlation between Vegetable and Fruit Intake and Cognitive Function in Older Adults: A Cross-Sectional Study in Chongqing, China

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This study examined how eating different types of fruits and vegetables affects brain health in older adults in Chongqing, China. Researchers found that higher fruit intake and eating more root vegetables (like carrots and turnips) were associated with better cognitive function and lower risk of mild cognitive impairment. Some vegetables like tomatoes and peppers also showed protective benefits, while leafy greens did not show a significant effect. The findings suggest that encouraging older adults to eat more fruits and certain vegetables could help prevent memory problems and cognitive decline.

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

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As we age, brain cells called excitatory neurons undergo senescence, similar to cellular ageing. This study found that a protein called GDF11 protects these neurons from ageing. When GDF11 was removed from excitatory neurons in mice, the neurons aged faster, leading to memory problems and shorter lifespans. The research reveals that GDF11 works by blocking p21, a molecule that promotes cellular ageing.

Disease: Cognitive decline