Disease: Cocaine Use Disorder

The Role of Psychedelics in the Treatment of Substance Use Disorders: An Overview of Systematic Reviews

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This research review examines how psychedelic drugs like psilocybin and ketamine might help treat addiction. Studies show these substances could help people quit alcohol, drugs, and smoking by reducing cravings and promoting long-term abstinence. While results are promising, scientists caution that more rigorous research is needed before these treatments can be recommended for regular medical use, and they acknowledge real risks associated with these powerful drugs.

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Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review

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This review examines how ketamine and psychedelics affect connections between brain cells. Under stressful conditions, ketamine and psychedelics appear to strengthen these connections in brain areas important for mood and learning. However, the effects are mixed under normal conditions and vary based on dose, sex, and which specific markers are measured. The findings suggest these substances may help restore brain function damaged by stress or substance use.

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Ketamine, Psychedelics, and Psychotherapy: Reframing, Redefining, Renaming Treatment Models

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This paper addresses confusion about how ketamine and psychedelics are being used to treat mental health conditions like depression and PTSD. The authors propose new clear definitions to distinguish whether these drugs are used alone for their chemical effects, combined with established talk therapies, or used to create experiences that are then processed in therapy. Using these clearer definitions will help patients, doctors, and regulators better understand what treatments involve and make more informed decisions.

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Survey of Massachusetts peer recovery coaches’ attitudes toward the use of psychedelics to treat substance use disorders

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Researchers surveyed peer recovery coaches in Massachusetts about their views on using psychedelics like psilocybin and ketamine to treat addiction. Most coaches felt comfortable supporting this approach and believed they should receive training, but many worried about potential risks and felt that traditional 12-step programs wouldn’t approve. Coaches with personal experience using psychedelics were more supportive than those who hadn’t tried them.

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Analysis of Psilocybin-Assisted Therapy in Medicine: A Narrative Review

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This review examines how psilocybin, the active compound in magic mushrooms, may help treat difficult-to-treat conditions like smoking addiction, alcohol dependence, and depression. Clinical trials show psilocybin-assisted therapy achieves better smoking cessation rates (80%) than standard medications and reduces depression symptoms as effectively as common antidepressants. The treatment works differently than daily medications, requiring only a few supervised doses weeks apart, potentially offering a new option for millions of people.

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Psychedelics: From Cave Art to 21st-Century Medicine for Addiction

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This comprehensive review examines how psychedelic substances, from magic mushrooms to LSD, are being studied as treatments for addiction. After decades of restriction, researchers are rediscovering what indigenous cultures have known for thousands of years: these substances can help people overcome alcohol, drug, and tobacco addiction. The research shows promising results, particularly when combined with therapy, with abstinence rates significantly higher than traditional treatments.

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