Disease: CNS infection

The emerging fungal pathogen Cryptococcus gattii: Epidemiology, pathogenesis, immunomodulatory attributes, and drug susceptibility

Cryptococcus gattii is a dangerous fungal infection that can affect even healthy people, unlike most fungal infections that target those with weak immune systems. The fungus uses clever tricks to hide from the immune system, including creating protective capsules and producing melanin. Current antifungal drugs like fluconazole are becoming less effective as the fungus develops resistance, making this an urgent public health concern that requires better treatments and early detection.

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Mechanisms of Talaromyces marneffei induced CNS injury: Synergistic roles of tauopathy, pyroptosis, and microglial inflammation

A dangerous fungus called Talaromyces marneffei can invade the brain and cause serious damage in people with weakened immune systems. The study shows the fungus harms brain cells through two pathways: direct damage to neurons and indirect damage through activation of brain immune cells that release harmful inflammatory chemicals. Understanding these mechanisms could help develop better treatments for this life-threatening infection.

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