cirrhosis – mycolab.ai

Ganoapplanilactone C from Ganoderma applanatum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

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Researchers found that a compound called ganoapplanilactone C from the medicinal mushroom Ganoderma applanatum can protect the liver from fat accumulation and damage caused by high-fat diets. In zebrafish studies, this compound worked better than a common cholesterol drug at reducing liver fat and improving liver health. The compound appears to work by activating a protein called AMPK that helps regulate how the body processes fats and reduces inflammation.

The Gut Mycobiome for Precision Medicine

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This comprehensive review explores how fungi in our gut play important roles in our health and disease. While fungi make up only a tiny fraction of our gut microbiota, they have outsized effects on conditions like diabetes, inflammatory bowel disease, and even certain cancers. The review discusses how scientists study these fungi and how understanding individual fungal profiles could lead to personalized medical treatments tailored to each person’s unique microbial makeup.

Edible Fungi Melanin: Recent Advances in Extraction, Characterization, Biological Activity and Applications

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Melanin from edible mushrooms like black wood ear and reishi offers a natural, sustainable alternative to synthetic melanins with impressive health benefits. These mushroom melanins demonstrate powerful antioxidant and antibacterial properties, protect against radiation damage, and can help maintain liver health. New extraction methods using special solvents are making it easier to obtain pure melanin from mushrooms efficiently, opening doors for its use in food, cosmetics, and medicines.

Candida blankii: The Difficult Capture of a Fungus With Pathogenic Potential

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Candida blankii is a rare fungal pathogen that is increasingly being found in hospital patients’ bloodstreams and respiratory tracts. The organism is difficult to identify using standard laboratory tests, which can delay diagnosis and treatment. This case report describes two adult patients with C. blankii infections and highlights the challenges in identifying this emerging pathogen and its resistance to common antifungal medications.

Influenza-related invasive pulmonary aspergillosis in an infectious disease ward at a pulmonary referral center in Iran

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This study examined patients hospitalized with influenza who developed a serious fungal infection caused by Aspergillus fungus. Among 109 influenza patients, about 9% developed this fungal complication which significantly increased their risk of death and required longer hospital stays. Patients with existing lung diseases were at higher risk, and those with the fungal infection also had more bacterial superinfections. The findings highlight the importance of recognizing and treating this serious fungal complication in hospitalized influenza patients.

Lectins as versatile tools to explore cellular glycosylation

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Lectins are natural proteins that selectively bind to sugars on cell surfaces, discovered over 130 years ago as tools for studying cell chemistry. They have become especially valuable in cancer research, revealing how cancer cells have abnormal sugar patterns that predict how aggressively they spread. Modern biotechnology now allows scientists to create enhanced lectin versions and use them in high-throughput screening to discover new disease markers and improve patient diagnosis.

Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

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This study examined fungi in the gut of people with fatty liver disease and found that certain fungal species are more common in diseased patients. By analyzing both gut fungi and blood chemicals, researchers discovered that fungi significantly influence metabolic substances related to liver health. A computer model combining information about gut fungi and bacteria could identify fatty liver disease with reasonable accuracy, suggesting that fungi could be useful for disease diagnosis and potential treatment.

Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn’s disease

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This article explores how fungi, particularly Candida species, contribute to inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. The fungal microbiota becomes imbalanced in IBD patients, triggering harmful immune responses and worsening inflammation. The researchers propose that measuring specific Candida levels could help doctors diagnose disease severity and predict treatment response, opening new possibilities for personalized IBD management.

Comparative Efficacy of Antrodia cinnamomea on Liver Function Biomarkers in Mice and Rats: A Network Meta-Analysis

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This study compared different extracts from a medicinal mushroom called Antrodia cinnamomea to see which ones work best for protecting liver health. Researchers analyzed data from multiple animal studies and found that extracts rich in compounds called triterpenoids were the most effective at improving liver function and reducing inflammation. The findings suggest that this mushroom could potentially become a natural treatment option for liver disease in the future.

The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients

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This case report describes two rare instances where fungal infections were transmitted from organ donors to heart transplant recipients. One involved a Candida infection and the other involved Aspergillus fungus, both causing serious bloodstream and heart infections. The patients required extensive antifungal medications and multiple surgeries to survive their infections, though they experienced significant complications. These cases highlight the importance of careful screening of organ donors for undetected infections.

Disease: cirrhosis