Chronic kidney disease – Page 2

A prospective, multicenter study of invasive fungal disease caused by molds in children and adults in Chile

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Researchers studied serious fungal infections caused by molds in Chilean hospitals and found that aspergillus was the most common culprit, affecting both children and adults. Many patients with these infections were also suffering from COVID-19, showing how serious respiratory viruses can increase the risk of fungal complications. Good news: the study found no resistance to common antifungal medications in Chile yet, though overall survival rates remain concerning at around 60% at three months.

Superficial abdominal surgical site infection caused by Aspergillus welwitschiae: a case report

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An elderly woman developed a rare fungal infection in her abdominal surgical wound after surgery for a perforated colon. The infection was caused by Aspergillus welwitschiae, a mold that was initially thought to be a more common species. Doctors treated the infection by surgically removing the infected tissue and giving the patient an antifungal medication called voriconazole. This is the first reported case of this particular mold causing this type of surgical infection.

Increased Rates of Supplement-Associated Oxalate Nephropathy During COVID-19 Pandemic

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During the COVID-19 pandemic, more people took dietary supplements and high-dose vitamin C for health reasons. However, this study found that excessive supplement intake led to a significant increase in a kidney disease called oxalate nephropathy, where calcium oxalate crystals damage the kidneys. The good news is that when patients stopped taking these harmful supplements, their kidney function often improved, emphasizing the importance of careful supplement use.

Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model

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This study examined whether consuming large amounts of Chaga mushroom can damage the kidneys in rats. The researchers found that high-dose Chaga consumption led to kidney injury through accumulation of oxalate (a naturally occurring compound in the mushroom), causing oxidative damage and cell death in kidney tissue. The findings suggest that while Chaga mushroom is promoted as a health supplement, excessive long-term consumption may harm kidney function, particularly in susceptible individuals.

Influenza-related invasive pulmonary aspergillosis in an infectious disease ward at a pulmonary referral center in Iran

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This study examined patients hospitalized with influenza who developed a serious fungal infection caused by Aspergillus fungus. Among 109 influenza patients, about 9% developed this fungal complication which significantly increased their risk of death and required longer hospital stays. Patients with existing lung diseases were at higher risk, and those with the fungal infection also had more bacterial superinfections. The findings highlight the importance of recognizing and treating this serious fungal complication in hospitalized influenza patients.

Cryptococcus: Emerging host risk factors for infection

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This scientific review examines why some people without HIV are getting serious Cryptococcus infections and becoming very sick. Researchers found that people with liver problems, kidney disease, diabetes, cancer, and autoimmune diseases face much higher risk. The review also identifies new drugs and therapies that can surprisingly increase infection risk, highlighting the importance of understanding individual patient factors when treating these dangerous fungal infections.

Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress

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Researchers studied a natural supplement made from reishi mushroom and black locust flower to treat kidney disease. In laboratory and animal tests, this supplement reduced kidney damage by lowering harmful molecules called free radicals and controlling inflammation. The supplement worked by blocking specific pathways that cause kidney inflammation and scarring, suggesting it could be a helpful natural treatment for people with chronic kidney disease.

Data analysis of patients with positive mould or dimorphic fungal cultures from sterile sites

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This study examined 48 patients with serious mould and fungal infections at a South African hospital between 2014-2017. Most infections occurred in people with weak immune systems, especially those with HIV. The most common fungal type was Aspergillus. Even with appropriate antifungal medicines, one-quarter of patients died, highlighting how serious these infections can be.

Clinical spectrum, immune status, and prognostic factors of cryptococcosis: insights from a large, multi-center, ambispective cohort study in southeastern China

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This study examined cryptococcosis, a serious fungal infection, in 396 non-HIV patients across hospitals in southeastern China. The researchers found that patients’ immune status, whether the infection spread to the brain, and blood inflammation markers were key predictors of survival. Most patients treated with azole medications (a common antifungal) improved or recovered, though those with brain involvement or severe immune deficiency had worse outcomes. The findings help doctors identify which patients need more intensive treatment.

Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study

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This study analyzed over 4,000 research papers published between 2014 and 2024 about how oxidative stress damages kidneys in diabetic patients. Researchers found that China and the United States lead this research field, with increasing focus on natural compounds and traditional medicines that can reduce harmful reactive oxygen species. The findings suggest future treatments for diabetic kidney disease should target oxidative stress through both conventional drugs and natural antioxidant compounds derived from plants and fungi.

Disease: Chronic kidney disease