Disease: Candida infection

Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis

This research examines why some fungal infections of the nails resist treatment with the antifungal drug itraconazole. Scientists found that resistant fungi produce more proteins that pump the drug out of their cells (efflux pumps) and form protective biofilm structures. Understanding these resistance mechanisms could help develop better combination treatments that work alongside antifungal drugs to overcome resistance.

Read More »

Antifungal persistence: Clinical relevance and mechanisms

Some fungal infections don’t respond well to antifungal medications even though the fungi aren’t drug-resistant. This happens because a small percentage of fungal cells enter a dormant, low-energy state that protects them from being killed by the drugs. Understanding how these persistent cells survive and finding ways to target them could help prevent recurring fungal infections and improve treatment outcomes.

Read More »

Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis

Researchers studied why some fungal nail infections caused by Candida albicans stop responding to the antifungal drug itraconazole. They found that resistant fungal cells have higher activity of genes that pump the drug out of cells and produce slimy protective coatings called biofilms. These resistant fungi also formed less dense biofilms when the drug was present from the start. Understanding these resistance mechanisms could help develop new treatments by targeting the pump systems or breaking down the protective biofilm layers.

Read More »

Effects of Short-Chain Fatty Acid Combinations Relevant to the Healthy and Dysbiotic Gut upon Candida albicans

Short-chain fatty acids produced by healthy gut bacteria appear to slow the growth and reduce the invasive characteristics of Candida albicans, a fungus that normally lives harmlessly in the gut but can cause infections when the microbiota is disrupted by antibiotics. This study tested whether healthy gut SCFA levels inhibit Candida more effectively than dysbiotic levels and found that the healthy SCFA mix was somewhat more effective at preventing fungal hyphal formation, which is important for tissue invasion. However, different Candida strains responded differently to the SCFAs, suggesting that individual variation affects how protective these bacterial metabolites can be.

Read More »

Investigating the Increasing Azole Resistance in Candida Infections Among Critically Ill Patients: Experience From a Tertiary-Level Setup in North India

This study tracked the increase in drug-resistant yeast infections in hospitalized patients in India from 2023 to 2025. The researchers found that common antifungal medications like fluconazole are becoming less effective, with resistance rates nearly doubling over the study period. The good news is that newer antifungal drugs called echinocandins remained highly effective. The findings highlight the need for better infection control measures and more careful use of antifungal medications.

Read More »
Scroll to Top