Candida albicans infection

Cwh8 moonlights as a farnesyl pyrophosphate phosphatase and is essential for farnesol biosynthesis in Candida albicans

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Candida albicans is a common fungus that causes serious infections in people with weakened immune systems. The fungus produces a molecule called farnesol that prevents it from growing in long filaments, which are associated with virulence. Researchers discovered that an enzyme called Cwh8 is absolutely essential for making farnesol, and when this enzyme is missing, the fungus becomes highly sensitive to the antifungal drug fluconazole, suggesting a potential strategy to overcome drug resistance.

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial

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This study tested whether Ganoderma lucidum, a medicinal mushroom used in traditional Asian medicine, could treat denture stomatitis as effectively as the standard treatment clotrimazole. Both treatments reduced pain and improved symptoms equally well over two weeks. The results suggest that Ganoderma lucidum could be a useful alternative for patients who don’t respond well to standard antifungal drugs.

Experimental research on fungal inhibition using dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase

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Researchers developed a new patch treatment for nail fungus using tiny dissolving needles that deliver antifungal medication directly into the skin near infected nails. The patch combines two active ingredients that work together to kill fungus and break down protective biofilm layers that make fungal infections hard to treat. Testing showed the patch was safe, effective, and delivered much more medication to the infected area compared to traditional creams or pills.

Synergistic potential and apoptosis induction of Bunium persicum essential oil and its pure components, cuminaldehyde and γ-terpinene, in combination with fluconazole on Candida albicans isolates: in vitro and in silico evaluation

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Researchers tested a spice-derived essential oil called Bunium persicum and two of its active compounds to see if they could work better with the antifungal drug fluconazole against drug-resistant yeast infections. They found that one component called cuminaldehyde was particularly effective and worked synergistically with fluconazole, meaning the combination was more powerful than either treatment alone. These natural compounds could potentially help treat fungal infections that no longer respond to standard medications, offering a promising approach using plant-based remedies alongside conventional drugs.

Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis

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Nail fungal infections caused by Candida albicans can be difficult to treat when the fungus becomes resistant to common antifungal medications like itraconazole. Researchers found that resistant strains have overactive genes that pump the drug out of fungal cells and genes that help the fungus form protective biofilm structures. Understanding these resistance mechanisms could lead to better combination treatments that block these protective strategies.

Drug repurposing to fight resistant fungal species: Recent developments as novel therapeutic strategies

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Fungal infections are becoming increasingly difficult to treat due to growing drug resistance, affecting millions of people worldwide each year. This research collection explores creative solutions by repurposing existing medications and developing new combination therapies that work better together against resistant fungal species. Studies show promising results combining common antibiotics like minocycline with antifungal drugs, and natural compounds from traditional medicine show potential for treating hard-to-treat infections like Candida and Aspergillus.

Evaluation of the Cytotoxicity and Antifungal Efficacy of Crocus sativus (saffron) Petals on Clinical Isolates of Candida albicans

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Researchers tested saffron petals as a natural antifungal treatment against Candida albicans, a common fungal infection. While the saffron extract was less potent than the standard drug fluconazole, it showed promise as a safer alternative with minimal toxicity to human cells. The findings suggest saffron petals could be a cost-effective herbal option for treating fungal infections, especially as resistance to conventional antifungals increases.

Characterizing antimicrobial activity of environmental Streptomyces spp. and oral bacterial and fungal isolates from Canis familiaris and Felis catus

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Researchers collected bacteria and fungi from the mouths of pet dogs and cats, as well as environmental soil bacteria, to search for natural antimicrobial compounds. They found that some of these microorganisms produce substances that can kill harmful bacteria like E. coli and fungi like Candida albicans, especially when combined with existing antifungal medications. Notably, one environmental bacterium (Streptomyces) produced a compound that was even effective against fungal strains resistant to common antifungal drugs, suggesting promising new treatment possibilities.

Hyphal swelling induced in the phagosome of macrophages

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When Candida albicans yeast cells are engulfed by immune cells called macrophages, they transform into thread-like hyphae. Researchers discovered that these hyphae sometimes develop swollen, bulbous compartments rather than maintaining their normal shape. Surprisingly, these swollen fungal cells survive much better inside the hostile macrophage environment than normal-shaped hyphae. This swelling appears to be a clever survival strategy that helps the fungus resist being killed by the immune system.

A Case Report of Candidiasis Cellulitis in Long-Term Corticosteroid Use

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A 54-year-old man developed a serious hand infection caused by Candida albicans, a yeast that normally lives harmlessly on human skin. The infection occurred because he had been taking large doses of corticosteroid injections for 15 years to help with breathing problems, which weakened his immune system. Doctors drained the infected area and treated him with antifungal medication, and he recovered completely, highlighting the importance of recognizing fungal infections in patients on long-term steroid therapy.

Disease: Candida albicans infection