cancer – Page 10 – mycolab.ai

Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis

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This research demonstrates that lentinan, a compound from shiitake mushrooms, can effectively inhibit melanoma (a dangerous skin cancer) in laboratory studies. The compound works by triggering cancer cells to self-destruct through a specific cellular pathway involving three key proteins: AKT, Nur77, and Bcl-2. Importantly, the treatment showed no significant toxic side effects in animal models, suggesting it could be developed as a new cancer therapy option.

Mycoremediation: Expunging environmental pollutants

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Fungi can be used to clean up environmental pollution from industrial waste, pesticides, and heavy metals. Unlike expensive chemical treatments, fungal mycoremediation is cost-effective and environmentally friendly. Fungi produce natural enzymes that break down harmful pollutants into harmless substances, making it a promising solution for protecting soil and water contamination.

Innovative Bioactive Nanofibrous Materials Combining Medicinal and Aromatic Plant Extracts and Electrospinning Method

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This research explains how scientists use a technique called electrospinning to create tiny, beneficial fibers from medicinal plants. By combining plant extracts like turmeric with biodegradable polymers, researchers create advanced materials that can deliver medicine, promote wound healing, and fight bacteria. These innovative fibers represent a natural approach to healthcare, bringing ancient plant wisdom into modern nanotechnology for practical medical applications.

The treasured giants: a current overview on agricultural, nutritional, bioactive, and economic potential of Macrocybe Species (Agaricales, Basidiomycota)

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Macrocybe mushrooms are giant edible fungi found in tropical regions worldwide that offer significant nutritional and health benefits. These mushrooms can be cultivated using agricultural waste materials like sawdust and straw, making them an economical crop. Rich in proteins, fibers, vitamins, and medicinal compounds, they possess antimicrobial and immune-boosting properties that could benefit human health.

The Nearly Complete Genome of Grifola frondosa and Light-Induced Genes Screened Based on Transcriptomics Promote the Production of Triterpenoid Compounds

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Researchers sequenced the complete genetic code of maitake mushroom (Grifola frondosa) and discovered how light exposure influences the production of beneficial compounds called triterpenoids. The high-quality genome assembly revealed 12,526 genes and showed that light triggers specific genes involved in making these medicinal compounds. This breakthrough provides a scientific foundation for growing maitake mushrooms with optimized levels of health-promoting substances.

Revitalization of the Endophytic Fungus Acremonium sp. MEP2000 and Its Impact on the Growth and Accumulation of Bioactive Compounds in Inonotus obliquus

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Researchers successfully revived a beneficial fungus called Acremonium sp. MEP2000 that had lost its effectiveness through repeated cultivation by adding birch bark powder and medicinal mushroom powder to its growth medium. When used to treat the medicinal fungus Inonotus obliquus (chaga), this revitalized fungal culture dramatically improved the growth and production of healthy bioactive compounds like polysaccharides and triterpenoids. This breakthrough offers a practical solution for large-scale production of medicinal fungi with enhanced therapeutic potential for treating cancer, diabetes, and inflammatory conditions.

Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products

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Mushrooms have been used for health for thousands of years and contain special compounds that help boost the immune system and fight cancer. Scientists have identified several key active ingredients in mushrooms like polysaccharides and proteins that can activate immune cells and reduce tumors. Some mushroom products like lentinan from shiitake mushrooms have already been approved as cancer treatments in Japan. While most evidence comes from lab studies, ongoing research suggests mushroom-based medicines could become important therapeutic options.

Comparative Metabolite Profiling Between Cordyceps sinensis and Other Cordyceps by Untargeted UHPLC-MS/MS

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This research compares the chemical compounds found in authentic Cordyceps sinensis with four similar but different Cordyceps species to identify which ones are real. Using advanced laboratory techniques, scientists detected thousands of chemical differences between the species. They found that genuine C. sinensis contains higher levels of specific beneficial compounds like nucleosides and certain fatty acids. These findings help consumers and merchants distinguish authentic Cordyceps from counterfeit products and lower-quality substitutes.

In vitro fermentation characteristics and prebiotic activity of herbal polysaccharides: a review

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This review explores how plant-based polysaccharides from traditional herbs can benefit our health by feeding good bacteria in our gut. When these polysaccharides are fermented by our gut microbiota, they break down into smaller compounds that produce short-chain fatty acids, which have anti-inflammatory and immune-boosting effects. The research shows that different herbs have different structures that are recognized by specific beneficial bacteria, which suggests we can develop personalized functional foods tailored to promote specific health benefits.

Mushroom-Based Supplements in Italy: Let’s Open Pandora’s Box

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Researchers tested 19 mushroom supplement products sold in Italy and found serious quality problems. Many supplements didn’t actually contain the mushroom species listed on their labels. Some products also contained toxic substances or inconsistent amounts of beneficial compounds. The study highlights the need for better regulation and manufacturing standards to ensure these popular health products are safe and effective.

Disease: cancer