cancer – mycolab.ai

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

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This comprehensive review examines how medicinal mushrooms contain natural compounds that can boost immune function, fight cancer cells, reduce inflammation, and protect nerve cells. Different mushroom species like reishi, shiitake, and maitake contain various active substances such as beta-glucans and triterpenes that work through multiple biological pathways. While laboratory and animal studies show promising results, more human clinical trials are needed to confirm effectiveness and establish safe dosing guidelines.

Overcoming Solubility Challenges: Micronization of Berberine Using the GAS Antisolvent Technique

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Berberine is a traditional medicinal compound that could treat many diseases but doesn’t work well in the body because it doesn’t dissolve in water. Researchers used a special technique with pressurized carbon dioxide to break berberine into much smaller particles. This made the particles dissolve 18% better in water, which could make berberine-based medicines more effective at treating diabetes, high cholesterol, and other conditions.

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

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This review explores how fungi produce remarkable chemical compounds that have been transformed into important medicines for over a century. Starting with penicillin in the 1940s, scientists have discovered dozens of fungal-derived drugs used to treat infections, prevent organ rejection, lower cholesterol, and fight cancer. Modern technology now allows researchers to discover and analyze these compounds much faster and with smaller samples than ever before.

Modern-Day Green Strategies for the Removal of Chromium from Wastewater

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Chromium from industries like leather tanning and metal plating contaminates water and soil, causing serious health problems including cancer and organ damage. Scientists have developed eco-friendly methods using bacteria, fungi, plants, and agricultural waste to remove chromium from polluted water at low cost. These biological treatment methods are more sustainable and affordable than traditional chemical approaches, offering a promising solution for cleaning up contaminated environments.

Transcriptome and Metabolome Reveal Accumulation of Key Metabolites with Medicinal Properties of Phylloporia pulla

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Scientists studied a medicinal fungus called Phylloporia pulla to understand which health-promoting compounds it produces and how it makes them. Using advanced genetic and chemical analysis tools, they discovered the fungus produces beneficial compounds like steroids and triterpenoids that have anti-inflammatory and anti-cancer properties, with production peaking around the middle of the fungus’s growth cycle. They identified six key genes that control the production of celastrol, a particularly valuable compound with potential to treat diseases like Alzheimer’s and cancer. This research helps explain why this fungus has been used traditionally in medicine and provides guidance for growing it to maximize production of these beneficial compounds.

Large-Scale Field Cultivation of Morchella and Relevance of Basic Knowledge for Its Steady Production

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Morels are valuable mushrooms worth hundreds of dollars per kilogram. China dramatically expanded morel farming from 2012 to 2022, but many farmers struggle with unstable harvests and profits. Scientists have discovered that successful morel cultivation requires careful attention to species selection, proper nutrition techniques, and understanding the complex mating systems of morel fungi. Better training and scientific knowledge could help make morel farming more reliable and profitable worldwide.

Exploring the Mechanisms of Amino Acid and Bioactive Constituent Formation During Fruiting Body Development in Lyophyllum decastes by Metabolomic and Transcriptomic Analyses

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This research study examined how Lyophyllum decastes mushrooms develop and accumulate their valuable nutrients and flavor compounds. Scientists found that amino acids and polysaccharides reach their highest levels when the mushroom is mature, ready for harvesting. By analyzing the genes and chemical changes during mushroom growth, researchers identified the specific pathways responsible for producing these beneficial compounds. This knowledge helps improve mushroom cultivation and confirms its value as a healthy functional food.

Special Issue: Marine-Derived Compounds Applied in Cardiovascular Disease

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This collection of studies explores how compounds from ocean sources like seaweed, fish, shrimp, and microalgae can help protect heart health and prevent cardiovascular diseases. Researchers examined various marine ingredients and found they can reduce inflammation, lower cholesterol, reduce blood pressure, and prevent blood clots. The findings suggest that marine-derived products could become safer, more affordable alternatives or complements to current heart disease medications while supporting sustainable ocean resource use.

Social acceptability of psilocybin-assisted therapy for existential distress at the end of life: A population-based survey

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This study surveyed 2,800 Canadians about their views on using psilocybin (a psychedelic compound from certain mushrooms) to help patients with terminal illnesses manage existential distress and anxiety. About 79% of respondents thought it was a reasonable medical option, and 85% believed the government should cover the costs. People who had previous experience with psilocybin, those exposed to palliative care, and those with progressive political views were most supportive of this therapy.

Antioxidant activity and phytochemical analysis of different varieties of barley (Hordeum vulgare L.) available in Pakistan

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Researchers analyzed five varieties of barley grown in Pakistan to determine their nutritional and health benefits. They found that all varieties contained beneficial compounds with antioxidant properties, with Jau-21 performing exceptionally well. These barley varieties are rich in protein, fiber, minerals, and compounds that may help protect against diseases like diabetes and heart disease, making them promising ingredients for developing healthy food products.

Disease: cancer