Disease: Bronchiectasis

First case of invasive Rasamsonia argillacea in a child with chronic granulomatous disease in Qatar

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A 16-year-old girl with a rare immune system disorder called chronic granulomatous disease developed a serious fungal infection caused by Rasamsonia argillacea, a fungus that is not commonly seen in clinical practice. The infection presented as a painful collection in her chest wall that required surgery and multiple antifungal medications. This is the first reported case of this particular fungal infection in the Arabian Peninsula, and successful treatment required a combination of drugs chosen based on laboratory testing of the fungus’s resistance patterns.

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Aspergillus Bronchitis at Localised Mucus Plug in an Immunocompetent Patient

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A 55-year-old woman developed a rare fungal infection called Aspergillus bronchitis in a mucus plug within her lung over a 9-year period. Although she was otherwise healthy with a normal immune system, the fungus gradually grew and eventually caused serious bleeding in her lungs. Doctors treated the bleeding with artery embolization and then surgically removed the affected lung tissue. The fungus was identified as Aspergillus udagawae, a type that is harder to treat with standard antifungal medications.

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Distribution of fungal agents in the respiratory system of patients with underlying lung diseases; molecular identification and antifungal susceptibility profiles

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This research examined fungal infections in hospitalized patients with lung diseases in Iran, identifying which fungi were most common and which antifungal medications worked best against them. Researchers found that Candida albicans and Aspergillus flavus were the most prevalent fungi, particularly in COPD patients. Notably, some Candida isolates showed resistance to certain antifungal drugs, particularly voriconazole. The study emphasizes the importance of proper fungal identification and susceptibility testing for effective treatment.

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A Case of Allergic Bronchopulmonary Mycosis Caused by Cordyceps farinosa, a Species of Caterpillar Fungi

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A woman developed a serious respiratory condition called allergic bronchopulmonary mycosis caused by Cordyceps farinosa, a fungus that normally infects insect larvae. She worked in a laboratory breeding mice in a mountainous area and developed persistent cough and congestion. Doctors identified the fungus using DNA testing and treated her by removing the fungal material from her airways and removing her from the workplace, which led to complete recovery.

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Diagnostic performance of Aspergillus-specific immunoglobulin G immunochromatographic and enzyme-linked immunosorbent assay testing in chronic pulmonary aspergillosis: comparative analysis across subtypes and influencing factors

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Chronic pulmonary aspergillosis (CPA) is a serious fungal lung infection that primarily affects people with existing lung conditions. This study compared two methods to detect the disease: a fast, portable test (ICT) and a traditional laboratory test (ELISA). The faster ICT test was more accurate overall and can provide results quickly in areas without advanced laboratory facilities. However, patients already taking antifungal medications had lower test accuracy with both methods.

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