biofilm-associated infections

Antibiofilm activity and bioactive phenolic compounds of ethanol extract from the Hericium erinaceus basidiome

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Researchers tested a lion’s mane mushroom extract for its ability to stop harmful bacteria from forming protective biofilms that make infections harder to treat. The extract showed strong activity against Proteus mirabilis bacteria, reducing biofilm formation by over 78%. The antibiofilm power comes mainly from two phenolic compounds: protocatechuic acid and p-coumaric acid. These findings suggest lion’s mane mushroom could be developed into natural supplements or food preservatives to prevent bacterial contamination.

Characterization of ORF19.7608 (PPP1), a biofilm-induced gene of Candida albicans

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Researchers studied a gene called PPP1 in Candida albicans, a common fungal infection in hospitals. They found that this gene is highly active when the fungus forms protective biofilms on medical devices like catheters. Although the protein appears in a distinctive spotted pattern only during biofilm formation, removing this gene did not prevent biofilm formation or affect how the fungus responds to stress or antifungal drugs.

Disease: biofilm-associated infections

Antibiofilm activity and bioactive phenolic compounds of ethanol extract from the Hericium erinaceus basidiome

Characterization of ORF19.7608 (PPP1), a biofilm-induced gene of Candida albicans