Disease: bacteremia

CRISPR-Cas9 enables efficient genome engineering of the strictly lytic, broad-host-range staphylococcal bacteriophage K

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Scientists have developed a new method to genetically engineer bacteriophages—viruses that infect bacteria—to fight antibiotic-resistant Staphylococcus aureus infections. Using CRISPR technology, they created a special phage that glows when it infects S. aureus cells, allowing doctors to quickly detect this dangerous pathogen in patient blood samples and other clinical samples. This engineered phage works against most S. aureus strains tested, regardless of their resistance to vancomycin, and could lead to new diagnostic tools and treatments for drug-resistant bacterial infections.

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Antibacterial and Antifungal Activity and Acute Toxicity of Crude Extracts From the Wild Edible Mushrooms Cantharellus veraecrucis, Cantharellus violaceovinosus, and Turbinellus floccosus

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Researchers tested extracts from three wild edible mushroom species found in Mexican forests for their ability to fight harmful bacteria and fungi. The extracts showed promise against disease-causing microorganisms, with one species particularly effective against agricultural plant pathogens. While the extracts showed moderate toxicity at high doses, the results suggest these mushrooms could be developed into natural pesticides or medicines.

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Atypical Cutaneous Manifestation of Mycosis Fungoides: A Case Report

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A 68-year-old woman with mycosis fungoides, a rare skin cancer, developed severe infected lesions after swimming in the ocean. Her wounds were infected with four different types of bacteria that had not been previously reported together in this disease. She was treated with antibiotics and improved, highlighting the importance of patients with this condition avoiding water exposure and maintaining regular medical care.

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Incidence and Risk Factors for Invasive Fungal Infection in Patients with Hematological Malignancies at a Tertiary Hospital in Malaysia

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This study examined fungal infections in cancer patients with blood disorders in a Malaysian hospital. Researchers found that about 7.6% of patients developed serious fungal infections, mainly from Candida species. Using antifungal medications to prevent infection significantly reduced the risk, though some patients still developed infections while taking preventive medications. The findings highlight the importance of appropriate antifungal treatment strategies in managing these vulnerable patients.

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Clinical insights into mixed Candida and bacterial bloodstream infections: a retrospective cohort study

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This study found that when both Candida fungus and bacteria are present together in a patient’s bloodstream, the outcome is much more serious than when only Candida is present. Among patients with these mixed infections, over 60% died within 30 days compared to about 52% for those with only Candida. The research shows that giving the right antibiotics early and following proper treatment guidelines can significantly improve survival chances in these severe, life-threatening infections.

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