Disease: aspergillus infections

In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species

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Researchers tested an old antibiotic called nitroxoline against dangerous fungal infections caused by Aspergillus species. The drug works by removing important minerals like zinc that these fungi need to survive. Testing showed nitroxoline was very effective against these fungi, even against strains that had developed resistance to modern antifungal drugs. This suggests nitroxoline could potentially be repurposed as a new treatment option for serious fungal infections.

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Evaluating the Potential of Galactosaminogalactan as a Diagnostic Target for Invasive Aspergillosis

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Researchers developed a new test to detect Aspergillus fungal infections using an antibody that recognizes a fungal component called GAG. The test worked very well in mouse studies, reliably detecting the fungus in blood and other body fluids. However, when tested with samples from infected patients, the test could not find GAG in the blood or other fluids, though it could see the fungus in lung tissue. This suggests either patients don’t produce enough GAG in their bloodstream, or something in human biology interferes with detection.

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Efficacy and safety of isavuconazole for invasive fungal infections: A systematic review and meta-analysis of randomized controlled trials

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This study reviewed clinical trials comparing a newer antifungal drug called isavuconazole with other commonly used antifungal medications for treating serious fungal infections, particularly in patients with weakened immune systems. The research found that isavuconazole works just as well as other antifungal drugs but may have fewer side effects, especially liver problems. When compared directly with voriconazole, isavuconazole showed fewer drug-related side effects overall, making it a good alternative option for patients who cannot tolerate other antifungal treatments.

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